C57BL/6JCya-Obp2aem1/Cya
Common Name
Obp2a-KO
Product ID
S-KO-16576
Backgroud
C57BL/6JCya
Strain ID
KOCMP-227627-Obp2a-B6J-VB
When using this mouse strain in a publication, please cite “Obp2a-KO Mouse (Catalog S-KO-16576) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Obp2a-KO
Strain ID
KOCMP-227627-Obp2a-B6J-VB
Gene Name
Product ID
S-KO-16576
Gene Alias
Lcn13
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000077667
NCBI RefSeq
NM_153558
Target Region
Exon 2~3
Size of Effective Region
~0.9 kb
Overview of Gene Research
Obp2a, an odorant-binding protein, has diverse functions. It may be involved in lipid-related processes as it can bind and export fatty acids in yeast cells [4]. In the skin, it protects epidermal keratinocytes against cytotoxic small hydrophobic molecules and regulates epidermal barrier function [2]. It also seems to play a role in the olfactory system of locusts, being co-localized with IR8a in sensilla chaetica on the palps and involved in aldehyde detection [3].
In prostate cancer, tumor-derived OBP2A promotes castration-resistant prostate cancer (CRPC). Knockdown of OBP2A significantly inhibits CRPC and metastatic CRPC development, and treatment with its binding ligand α-pinene suppresses CRPC development [1]. In a three-dimensional epidermal equivalent model, silencing of OBP2A impairs epidermal barrier function, disrupts keratinocyte lipid metabolism, and induces endoplasmic reticulum stress [2].
In summary, Obp2a has crucial functions in protecting the skin from harmful molecules and in the development of castration-resistant prostate cancer. Gene knockdown models in both cancer cells and skin-equivalent models have been valuable in revealing these functions, highlighting its significance in skin-related and cancer-related biological processes.
References:
1. Jeong, Ji-Hak, Zhong, Shangwei, Li, Fuzhuo, Dhillon, Jasreman, Luo, Jun-Li. 2022. Tumor-derived OBP2A promotes prostate cancer castration resistance. In The Journal of experimental medicine, 220, . doi:10.1084/jem.20211546. https://pubmed.ncbi.nlm.nih.gov/36547668/
2. Nakanishi, Shinobu, Hasegawa, Tatsuya, Maeno, Katsuyuki, Motoyama, Akira, Denda, Mitsuhiro. 2024. OBP2A regulates epidermal barrier function and protects against cytotoxic small hydrophobic molecules. In iScience, 27, 111093. doi:10.1016/j.isci.2024.111093. https://pubmed.ncbi.nlm.nih.gov/39502293/
3. Zhang, Liwei, Li, Hongwei, Zhang, Long. 2017. Two Olfactory Pathways to Detect Aldehydes on Locust Mouthpart. In International journal of biological sciences, 13, 759-771. doi:10.7150/ijbs.19820. https://pubmed.ncbi.nlm.nih.gov/28656001/
4. Ekim Kocabey, Aslihan, Schneiter, Roger. 2024. Human lipocalins bind and export fatty acids through the secretory pathway of yeast cells. In Frontiers in microbiology, 14, 1309024. doi:10.3389/fmicb.2023.1309024. https://pubmed.ncbi.nlm.nih.gov/38328584/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.