C57BL/6JCya-Saa2em1/Cya
Common Name
Saa2-KO
Product ID
S-KO-16602
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20209-Saa2-B6J-VB
When using this mouse strain in a publication, please cite “Saa2-KO Mouse (Catalog S-KO-16602) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Saa2-KO
Strain ID
KOCMP-20209-Saa2-B6J-VB
Gene Name
Product ID
S-KO-16602
Gene Alias
Saa-2, Saa1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000210769
NCBI RefSeq
NM_011314
Target Region
Exon 3~4
Size of Effective Region
~1.8 kb
Overview of Gene Research
Saa2 is a member of the Serum Amyloid A (SAA) protein family. SAA proteins are small, well-conserved in mammalian evolution, and are mainly synthesized in the liver. Saa2, along with SAA1, is a prominent member of the acute-phase response, and their serum levels rise significantly after trauma, infection, etc. Saa2 is lipophilic and contributes to high-density lipoproteins and cholesterol transport. It also participates in various biological processes such as tissue remodeling, immune regulation, and has been implicated in many diseases [1].
In a mouse model of intrauterine inflammation, placental Saa2 increased significantly. Maternal inhibition of Saa2 using siSaa2 markedly decreased preterm birth and downregulated the increased placental expression of pro-inflammatory cytokines Il1β, Il6, and Tnfα, suggesting Saa2 may be a key factor in the mechanism of preterm birth [2]. In another study, Lactobacillus intestinalis decreased C/EBPA-driven gut epithelial Saa2 production, which in turn impaired Th17 cell differentiation, indicating Saa2's role in colitis-related Th17 response [3].
In conclusion, Saa2 is involved in important biological functions including acute-phase response, lipid transport, and immune regulation. Studies using gene-targeting mouse models, like siRNA-mediated Saa2 silencing, have revealed its role in diseases such as preterm birth and colitis, providing potential therapeutic targets for these conditions.
References:
1. Sack, George H. . Serum Amyloid A (SAA) Proteins. In Sub-cellular biochemistry, 94, 421-436. doi:10.1007/978-3-030-41769-7_17. https://pubmed.ncbi.nlm.nih.gov/32189310/
2. Liu, Yang, Liu, Jin, Liu, Anguo, Burd, Irina, Lei, Jun. 2022. Maternal siRNA silencing of placental SAA2 mitigates preterm birth following intrauterine inflammation. In Frontiers in immunology, 13, 902096. doi:10.3389/fimmu.2022.902096. https://pubmed.ncbi.nlm.nih.gov/36211368/
3. Wang, Qi-Wen, Jia, Ding-Jia-Cheng, He, Jia-Min, Wang, Liang-Jing, Chen, Shu-Jie. 2023. Lactobacillus Intestinalis Primes Epithelial Cells to Suppress Colitis-Related Th17 Response by Host-Microbe Retinoic Acid Biosynthesis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10, e2303457. doi:10.1002/advs.202303457. https://pubmed.ncbi.nlm.nih.gov/37983567/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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