C57BL/6JCya-As3mtem1/Cya
Common Name:
As3mt-KO
Product ID:
S-KO-16760
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
As3mt-KO
Strain ID
KOCMP-57344-As3mt-B6J-VA
Gene Name
Product ID
S-KO-16760
Gene Alias
2310045H08Rik; Cyt19
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
19
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-As3mtem1/Cya mice (Catalog S-KO-16760) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000003655
NCBI RefSeq
NM_020577
Target Region
Exon 4
Size of Effective Region
~0.1 kb
Detailed Document
Overview of Gene Research
As3mt, also known as arsenic (3) methyltransferase, is a key enzyme in arsenic metabolism. It catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to trivalent arsenical, participating in the methylation steps of inorganic arsenic (iAs) metabolism, which forms methylated arsenite and other metabolites [2,3]. This process is crucial as arsenic exposure is linked to various health issues, and As3mt is involved in related pathways that impact health. Genetic models, like humanized mouse models, are valuable for studying its functions.
In arsenic-induced non-alcoholic fatty liver disease (NAFLD), As3mt plays a significant role. Chronic arsenic exposure increases As3mt levels, and it blocks m6A-mediated miR-142-5p maturation by consuming SAM. This leads to elevated levels of SREBP1 and lipogenic genes, causing liver steatosis. SAM supplementation or As3mt deficiency can block arsenic-induced lipid accumulation by promoting miR-142-5p maturation [1]. In humanized As3mt mice exposed to arsenic, sex divergence in diabetes-related markers was detected, suggesting that humanized males may be at increased risk for metabolic dysfunction [4].
In conclusion, As3mt is essential for arsenic metabolism. Model-based research, especially with mouse models, has revealed its role in diseases such as NAFLD and arsenic-related metabolic diseases. Understanding As3mt provides insights into the mechanisms of arsenic-induced diseases, potentially offering new strategies for prevention and treatment.
References:
1. Li, Han, Wu, Lu, Ye, Fuping, Zhang, Aihua, Liu, Qizhan. 2023. As3MT via consuming SAM is involved in arsenic-induced nonalcoholic fatty liver disease by blocking m6A-mediated miR-142-5p maturation. In The Science of the total environment, 892, 164746. doi:10.1016/j.scitotenv.2023.164746. https://pubmed.ncbi.nlm.nih.gov/37301390/
2. Mersaoui, Sofiane Y, Guilbert, Cynthia, Chou, Hsiang, Richard, Stéphane, Mann, Koren K. 2022. Arsenic 3 methyltransferase (AS3MT) automethylates on cysteine residues in vitro. In Archives of toxicology, 96, 1371-1386. doi:10.1007/s00204-022-03248-8. https://pubmed.ncbi.nlm.nih.gov/35244730/
3. Agusa, Tetsuro, Fujihara, Junko, Takeshita, Haruo, Iwata, Hisato. 2011. Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms. In International journal of molecular sciences, 12, 2351-82. doi:10.3390/ijms12042351. https://pubmed.ncbi.nlm.nih.gov/21731446/
4. Todero, Jenna, Douillet, Christelle, Shumway, Alexandria J, Stýblo, Miroslav, Sethupathy, Praveen. 2023. Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice. In Environmental health perspectives, 131, 127021. doi:10.1289/EHP12785. https://pubmed.ncbi.nlm.nih.gov/38150313/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen