C57BL/6JCya-Ube2iem1/Cya
Common Name:
Ube2i-KO
Product ID:
S-KO-17365
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ube2i-KO
Strain ID
KOCMP-22196-Ube2i-B6J-VA
Gene Name
Product ID
S-KO-17365
Gene Alias
5830467E05Rik; UBC9; Ubce2i; Ubce9
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ube2iem1/Cya mice (Catalog S-KO-17365) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000172618
NCBI RefSeq
NM_001177609
Target Region
Exon 3~8
Size of Effective Region
~8.9 kb
Detailed Document
Overview of Gene Research
Ube2i, also known as ubiquitin-conjugating enzyme E2I or UBC9, is the sole small ubiquitin-like modifier (SUMO) E2-conjugating enzyme. SUMOylation, a post-translational modification process it is involved in, regulates various cellular functions such as protein subcellular localization, transcription, and the cell cycle [1,2,3]. It is important in multiple biological processes and is associated with various diseases.
In adipocytes, deletion of Ube2i in mice (Ube2ia-KO) using Nuclease technology gene editing and subsequent genetic crosses led to lipoatrophy. These mice developed hyperinsulinemia, hepatic steatosis, and global energy balance defects due to dysfunctional white adipose tissue (WAT) with inflammation, loss of adipokines, and hepatomegaly. This shows that Ube2i in mature adipocytes is crucial for WAT expansion during postnatal growth [1]. In cholangiocarcinoma, knockdown of Ube2i inhibited cell proliferation, delayed xenograft tumor growth, and sensitized cells to chemotherapeutics, likely due to p27kip1 nuclear accumulation and cell cycle arrest [3]. In ovarian cancer, depletion of Ube2i regulated tumor-associated macrophage polarization into M1 type through reprogramming glycolysis and increased the efficacy of anti-PD-L1 immunotherapy [4].
In conclusion, Ube2i is essential for various biological functions. Studies using Ube2i KO mouse models have revealed its significance in adipocyte function and energy balance, as well as in cancer-related processes such as tumorigenesis and immunotherapy response. These findings provide insights into potential therapeutic targets for diseases like lipoatrophy-related metabolic disorders and certain cancers.
References:
1. Cox, Aaron R, Chernis, Natasha, Kim, Kang Ho, Pangas, Stephanie A, Hartig, Sean M. 2021. Ube2i deletion in adipocytes causes lipoatrophy in mice. In Molecular metabolism, 48, 101221. doi:10.1016/j.molmet.2021.101221. https://pubmed.ncbi.nlm.nih.gov/33771728/
2. Xu, Honggang, Xu, Bin. 2024. UBE2I regulates the nuclear translocation of hnRNPA2B1 by contributing to SUMO modification in osteoarthritis. In Gene, 927, 148740. doi:10.1016/j.gene.2024.148740. https://pubmed.ncbi.nlm.nih.gov/38955308/
3. Huang, Jie, Tan, Xiaolong, Liu, Yan, Jiang, Kainian, Luo, Jian. 2023. Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export. In Molecular carcinogenesis, 62, 700-715. doi:10.1002/mc.23518. https://pubmed.ncbi.nlm.nih.gov/36825757/
4. Zhao, Lei, Zhang, Yuxin, Wang, Jinming, Li, Dongliang, Hao, Xuewei. 2025. UBE2I depletion regulated tumor-associated macrophage polarization into M1 type through reprogramming glycolysis and increases immunotherapy efficacy of anti-PD-L1 in ovarian cancer. In Molecular immunology, 179, 29-41. doi:10.1016/j.molimm.2025.01.007. https://pubmed.ncbi.nlm.nih.gov/39919348/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen