C57BL/6JCya-S100a10em1/Cya
Common Name
S100a10-KO
Product ID
S-KO-17548
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20194-S100a10-B6J-VA
When using this mouse strain in a publication, please cite “S100a10-KO Mouse (Catalog S-KO-17548) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
S100a10-KO
Strain ID
KOCMP-20194-S100a10-B6J-VA
Gene Name
Product ID
S-KO-17548
Gene Alias
42C, CAL12, CLP11, Cal1l, p10, p11
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000045756
NCBI RefSeq
NM_009112
Target Region
Exon 2
Size of Effective Region
~0.2 kb
Overview of Gene Research
S100A10, also known as p11 or annexin 2 light chain, is a member of the S100 family of calcium - binding proteins. Uniquely, it does not bind to Ca2+ despite sequence and structural similarities to other family members. It mainly binds to annexin A2 to form a heterotetrameric complex (AIIt), which is crucial for the conversion of plasminogen to plasmin, a process involved in multiple physiological processes such as fibrinolysis, angiogenesis, and wound healing [2,3,4,5,7].
In cancer research, S100A10 - deficient mice have shown reduced cancer metastasis in the lung [6]. Tumor - derived exosomes can activate S100A10 in lung fibroblasts, increasing the expression of CXCL1 and CXCL8 chemokines and recruiting myeloid - derived suppressor cells (MDSCs), thus promoting cancer metastasis. In hepatocellular carcinoma (HCC), S100A10 promotes HCC initiation, self - renewal, chemoresistance, and metastasis both in vitro and in vivo. S100A10 is secreted by HCC cells into extracellular vesicles (EVs), and EV - S100A10 enhances the stemness and metastatic ability of HCC cells, upregulates epidermal growth factor receptor (EGFR), AKT, and ERK signalling, and promotes epithelial - mesenchymal transition [1].
In conclusion, S100A10 plays a significant role in physiological processes related to plasmin generation. In disease, especially cancer, S100A10 - related KO mouse models have revealed its promoting effect on cancer metastasis, highlighting its potential as a therapeutic target and biomarker, especially in lung cancer and HCC [1,6].
References：
1. Wang, Xia, Huang, Hongyang, Sze, Karen Man-Fong, Guan, Xinyuan, Ng, Irene Oi-Lin. 2023. S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos. In Gut, 72, 1370-1384. doi:10.1136/gutjnl-2022-327998. https://pubmed.ncbi.nlm.nih.gov/36631249/
2. Bharadwaj, Alamelu G, Kempster, Emma, Waisman, David M. 2021. The ANXA2/S100A10 Complex-Regulation of the Oncogenic Plasminogen Receptor. In Biomolecules, 11, . doi:10.3390/biom11121772. https://pubmed.ncbi.nlm.nih.gov/34944416/
3. Tantyo, Normastuti Adhini, Karyadi, Azrina Saraswati, Rasman, Siti Zulimas, Devina, Astrella, Sumarpo, Anton. 2018. The prognostic value of S100A10 expression in cancer. In Oncology letters, 17, 1417-1424. doi:10.3892/ol.2018.9751. https://pubmed.ncbi.nlm.nih.gov/30675195/
4. Saiki, Yuriko, Horii, Akira. 2019. Multiple functions of S100A10, an important cancer promoter. In Pathology international, 69, 629-636. doi:10.1111/pin.12861. https://pubmed.ncbi.nlm.nih.gov/31612598/
5. Noye, Tannith M, Lokman, Noor A, Oehler, Martin K, Ricciardelli, Carmela. 2018. S100A10 and Cancer Hallmarks: Structure, Functions, and its Emerging Role in Ovarian Cancer. In International journal of molecular sciences, 19, . doi:10.3390/ijms19124122. https://pubmed.ncbi.nlm.nih.gov/30572596/
6. Li, Juan, Zhou, Can, Gao, Xiaoqian, Liu, Jie, Liu, Peijun. 2024. S100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs. In Oncoimmunology, 13, 2381803. doi:10.1080/2162402X.2024.2381803. https://pubmed.ncbi.nlm.nih.gov/39071160/
7. Bharadwaj, Alamelu, Kempster, Emma, Waisman, David Morton. 2021. The Annexin A2/S100A10 Complex: The Mutualistic Symbiosis of Two Distinct Proteins. In Biomolecules, 11, . doi:10.3390/biom11121849. https://pubmed.ncbi.nlm.nih.gov/34944495/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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