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C57BL/6JCya-Slc7a8em1/Cya
Common Name:
Slc7a8-KO
Product ID:
S-KO-17732
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc7a8-KO
Strain ID
KOCMP-50934-Slc7a8-B6J-VB
Gene Name
Slc7a8
Product ID
S-KO-17732
Gene Alias
LAT2
Background
C57BL/6JCya
NCBI ID
50934
Modification
Conventional knockout
Chromosome
14
Phenotype
MGI:1355323
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc7a8em1/Cya mice (Catalog S-KO-17732) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022787
NCBI RefSeq
NM_016972
Target Region
Exon 2~7
Size of Effective Region
~27.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Slc7a8, encoding the L-type amino acid transporter 2 (LAT2), is a gene that plays a crucial role in amino acid transport. It is involved in the transportation of arginine, large amino acids, and L-DOPA [2,3]. This gene is associated with pathways related to cell metabolism, proliferation, and immune responses. Genetic models, such as knockout mouse models, have been valuable in studying its functions.

In a diet-induced obesity mouse model, Slc7a8 knockout (KO) mice gained significantly less weight than wild-type mice on a high-fat diet. KO mice also had reduced adipocyte mass, hypertrophy, and macrophage infiltration in adipose depots, along with decreased lipid accumulation in multiple organs, indicating that Slc7a8 deletion protects against diet-induced obesity [1]. In the context of type 2 innate lymphoid cells (ILC2), genetic ablation of Slc7a8 in lymphocytes reduced the frequency of ILC2s, suppressed cytokine production, and impaired type 2 immune responses, identifying Slc7a8 as a key amino acid supplier for ILC2 functions [2].

In summary, Slc7a8 is essential for amino acid-related metabolic processes. Its deletion in KO mouse models has revealed its role in protecting against diet-induced obesity and in maintaining ILC2 functions. These findings contribute to our understanding of obesity-related diseases and immune-related conditions, highlighting the importance of Slc7a8 in these biological contexts.

References:
1. Pitere, Reabetswe R, van Heerden, Marlene B, Pepper, Michael S, Ambele, Melvin A. 2022. Slc7a8 Deletion Is Protective against Diet-Induced Obesity and Attenuates Lipid Accumulation in Multiple Organs. In Biology, 11, . doi:10.3390/biology11020311. https://pubmed.ncbi.nlm.nih.gov/35205177/
2. Panda, Santosh K, Kim, Do-Hyun, Desai, Pritesh, Van Dyken, Steven J, Colonna, Marco. 2022. SLC7A8 is a key amino acids supplier for the metabolic programs that sustain homeostasis and activation of type 2 innate lymphoid cells. In Proceedings of the National Academy of Sciences of the United States of America, 119, e2215528119. doi:10.1073/pnas.2215528119. https://pubmed.ncbi.nlm.nih.gov/36343258/
3. Wu, Yihao, Yin, Qiqi, Lin, Su, Zhang, Xingwei, Yang, Deye. 2017. Increased SLC7A8 expression mediates L-DOPA uptake by renal tubular epithelial cells. In Molecular medicine reports, 16, 887-893. doi:10.3892/mmr.2017.6620. https://pubmed.ncbi.nlm.nih.gov/28560461/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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