C57BL/6JCya-Tmem120bem1/Cya
Common Name
Tmem120b-KO
Product ID
S-KO-17782
Backgroud
C57BL/6JCya
Strain ID
KOCMP-330189-Tmem120b-B6J-VB
When using this mouse strain in a publication, please cite “Tmem120b-KO Mouse (Catalog S-KO-17782) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tmem120b-KO
Strain ID
KOCMP-330189-Tmem120b-B6J-VB
Gene Name
Product ID
S-KO-17782
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000067505
NCBI RefSeq
NM_001039723.2
Target Region
Exon 2~3
Size of Effective Region
~2.6 kb
Overview of Gene Research
Tmem120b is a transmembrane protein-encoding gene. It has been implicated in multiple biological functions such as adipocyte differentiation, with its paralog Tmem120A, where knockdown of these proteins impacts genes required for adipocyte differentiation and lipid accumulation [3]. It may also be involved in ion transport as its homolog TMEM120A has ion-transport capabilities [2].
In cancer research, TMEM120B expression is elevated in lung, breast, gastric, colon, and ovarian cancers. In breast cancer, overexpression of TMEM120B promotes cell proliferation, invasion, and stemness by activating the β1-integrin/FAK-TAZ-mTOR signaling axis through binding to MYH9, and also accelerates chemotherapy resistance. Conversely, overexpression of TMEM120B-∆CCD has the opposite effects [1].
In summary, Tmem120b plays important roles in adipocyte differentiation and in the context of cancer, especially breast cancer, where its function in promoting cancer cell stemness and chemotherapy resistance has been revealed through in-vitro and in-vivo-like mouse xenograft model studies. These findings contribute to our understanding of adipogenesis and cancer development, potentially guiding future research in these disease areas.
References：
1. Hu, Ran, Cao, Yu, Wang, Yuanyuan, Zhang, Yong, Zhang, Xiupeng. 2024. TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9. In Breast cancer research : BCR, 26, 48. doi:10.1186/s13058-024-01802-z. https://pubmed.ncbi.nlm.nih.gov/38504374/
2. Zhao, Changjian, Chen, Mutian, Liu, Xiaofeng, Deng, Dong, Geng, Jia. 2024. Direct single-molecule detection of CoA-SH and ATP by the membrane proteins TMEM120A and TMEM120B. In Nanoscale, 16, 6087-6094. doi:10.1039/d3nr05054h. https://pubmed.ncbi.nlm.nih.gov/38444242/
3. Batrakou, Dzmitry G, de Las Heras, Jose I, Czapiewski, Rafal, Mouras, Rabah, Schirmer, Eric C. 2015. TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation. In PloS one, 10, e0127712. doi:10.1371/journal.pone.0127712. https://pubmed.ncbi.nlm.nih.gov/26024229/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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