C57BL/6JCya-Tstem1/Cya
Common Name
Tst-KO
Product ID
S-KO-18077
Backgroud
C57BL/6JCya
Strain ID
KOCMP-22117-Tst-B6J-VA
When using this mouse strain in a publication, please cite “Tst-KO Mouse (Catalog S-KO-18077) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tst-KO
Strain ID
KOCMP-22117-Tst-B6J-VA
Gene Name
Product ID
S-KO-18077
Gene Alias
rhodanese
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000058659
NCBI RefSeq
NM_009437
Target Region
Exon 2
Size of Effective Region
~1.3 kb
Overview of Gene Research
Tst can refer to the gene encoding toxic shock syndrome toxin-1 (TSST-1) in Staphylococcus aureus. TSST-1 is an important virulence factor of tst-positive S. aureus, which can lead to multi-organ malfunction. The tst gene associated Staphylococcus aureus Pathogenicity Island may play a critical role in the pathological process of infection, promoting the secretion of inflammatory cytokines such as IL-6, IL-2 and IL17A, and inducing immune suppression [1].
The prevalence of the tst gene was approximately 17.8% among the examined bacterial strains. BALB/c mice infected with tst gene-associated SaPI positive isolates showed severe body weight loss, high bacterial load in multiple organs, and more severe tissue impairment [1].
In conclusion, the tst gene in S. aureus is crucial in the pathogenesis of infection. The animal experiments with BALB/c mice infected with tst-positive isolates have revealed its role in promoting inflammation and immune suppression, which is significant for understanding the mechanism of S. aureus-related diseases.
References：
1. Zheng, Yi, Qin, Chenhao, Zhang, Xianfeng, Zhang, Haifang, Du, Hong. 2019. The tst gene associated Staphylococcus aureus pathogenicity island facilitates its pathogenesis by promoting the secretion of inflammatory cytokines and inducing immune suppression. In Microbial pathogenesis, 138, 103797. doi:10.1016/j.micpath.2019.103797. https://pubmed.ncbi.nlm.nih.gov/31614194/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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