C57BL/6JCya-Calb1em1/Cya
Common Name:
Calb1-KO
Product ID:
S-KO-18229
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Calb1-KO
Strain ID
KOCMP-12307-Calb1-B6J-VB
Gene Name
Product ID
S-KO-18229
Gene Alias
Brain-2; CB; Calb; Calb-1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Calb1em1/Cya mice (Catalog S-KO-18229) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029876
NCBI RefSeq
NM_009788
Target Region
Exon 2
Size of Effective Region
~0.7 kb
Detailed Document
Overview of Gene Research
Calb1, also known as calbindin 1, is a calcium-binding protein. It plays a crucial role in regulating calcium-ion homeostasis, which is involved in various cellular processes such as autophagy, cell proliferation, and senescence. It may participate in pathways like the Ca2+-dependent calcineurin/NFAT pathway [4].
In chicken, CALB1 isolated from intestinal mucus significantly inhibits the replication of avian viruses, possibly by binding calcium ions and/or inducing autophagy [1].
In ovarian cancer, CALB1 acts as an oncogene by enhancing the interaction between p53 and MDM2, promoting cell proliferation and inhibiting senescence [2].
In aging mouse oocytes, knockdown of CALB1 leads to reduced calcium ion levels in the endoplasmic reticulum and mitochondria, resulting in mitochondrial dysfunction and meiotic defects, indicating its importance in maintaining oocyte quality [3].
In conclusion, Calb1 is essential for regulating calcium-ion-related cellular functions. Its study through model-based research, especially in diseases like ovarian cancer and in processes like oocyte aging, has provided insights into its role in disease development and reproductive health.
References：
1. Lu, Danqing, Wu, Yang, Fu, Mei, Lin, Jian, Yang, Qian. 2023. CALB1: Anovel antiviral factor in chicken ileal mucus. In International journal of biological macromolecules, 253, 127007. doi:10.1016/j.ijbiomac.2023.127007. https://pubmed.ncbi.nlm.nih.gov/37734520/
2. Cao, Long-Qiao, Wang, Ya-Nan, Liang, Ming, Pan, Mei-Zhou. 2019. CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells. In Molecular medicine reports, 19, 5097-5104. doi:10.3892/mmr.2019.10212. https://pubmed.ncbi.nlm.nih.gov/31059057/
3. Han, Yingxue, Du, Zihuan, Wu, Hao, Gao, Shuai, Zeng, Shenming. 2025. CALB1 and RPL23 Are Essential for Maintaining Oocyte Quality and Function During Aging. In Aging cell, , e14466. doi:10.1111/acel.14466. https://pubmed.ncbi.nlm.nih.gov/39748132/
4. Raynard, Clotilde, Tessier, Nolwenn, Huna, Anda, Martin, Nadine, Bernard, David. 2022. Expression of the Calcium-Binding Protein CALB1 Is Induced and Controls Intracellular Ca2+ Levels in Senescent Cells. In International journal of molecular sciences, 23, . doi:10.3390/ijms23169376. https://pubmed.ncbi.nlm.nih.gov/36012633/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen