C57BL/6JCya-Fosbem1/Cya
Common Name
Fosb-KO
Product ID
S-KO-18237
Backgroud
C57BL/6JCya
Strain ID
KOCMP-14282-Fosb-B6J-VB
When using this mouse strain in a publication, please cite “Fosb-KO Mouse (Catalog S-KO-18237) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Fosb-KO
Strain ID
KOCMP-14282-Fosb-B6J-VB
Gene Name
Product ID
S-KO-18237
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000003640
NCBI RefSeq
NM_008036
Target Region
Exon 2~3
Size of Effective Region
~0.9 kb
Overview of Gene Research
Fosb, short for FBJ Murine Osteosarcoma Viral Oncogene Homolog B, is a proto-oncogene. It belongs to the Fos family of transcription factors. As a transcription factor, Fosb can regulate the expression of specific target genes, thus participating in a wide variety of biological processes. It is involved in tumorigenic processes and may regulate neuronal excitability and synaptic plasticity in the nervous system [1,2,3].
In glioma, knockdown of FosB led to decreased cell viability, proliferation, and migration, suggesting FosB may promote glioma development and migration [4]. In APP mice, persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection to hippocampal dentate granule cells [2]. In mast cells of male mice, FosB/ΔFosB activation modulates allergic inflammation by regulating gene expression, likely through enhanced DUSP4 expression [5].
In conclusion, FosB plays significant roles in tumorigenesis, seizure regulation, and allergic inflammation. Gene-knockout or conditional-knockout mouse models have been crucial in revealing these functions, contributing to our understanding of related diseases such as glioma, epilepsy-related conditions in Alzheimer's disease models, and allergic inflammation.
References：
1. Cordier, Fleur, Creytens, David. 2023. New kids on the block: FOS and FOSB gene. In Journal of clinical pathology, 76, 721-726. doi:10.1136/jcp-2023-208931. https://pubmed.ncbi.nlm.nih.gov/37553246/
2. Stephens, Gabriel S, Park, Jin, Eagle, Andrew, Robison, A J, Chin, Jeannie. 2024. Persistent ∆FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice. In Progress in neurobiology, 237, 102612. doi:10.1016/j.pneurobio.2024.102612. https://pubmed.ncbi.nlm.nih.gov/38642602/
3. Nestler, Eric J. 2014. ∆FosB: a transcriptional regulator of stress and antidepressant responses. In European journal of pharmacology, 753, 66-72. doi:10.1016/j.ejphar.2014.10.034. https://pubmed.ncbi.nlm.nih.gov/25446562/
4. Qi, Min, Sun, Le-An, Zheng, Lan-Rong, Jiang, Xiao-Chun, Zhou, Meng-Liang. 2022. Expression and potential role of FOSB in glioma. In Frontiers in molecular neuroscience, 15, 972615. doi:10.3389/fnmol.2022.972615. https://pubmed.ncbi.nlm.nih.gov/36311014/
5. Duque-Wilckens, Natalia, Joseph, Dimitri, Syed, Meesum, Moesers, Adam J, Robison, A J. 2025. FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice. In bioRxiv : the preprint server for biology, , . doi:10.1101/2024.05.06.592755. https://pubmed.ncbi.nlm.nih.gov/38766119/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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