C57BL/6JCya-Gjd2em1/Cya
Common Name:
Gjd2-KO
Product ID:
S-KO-18475
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Gjd2-KO
Strain ID
KOCMP-14617-Gjd2-B6J-VB
Gene Name
Product ID
S-KO-18475
Gene Alias
Cxns; Gja9; connexin36; cx36
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gjd2em1/Cya mice (Catalog S-KO-18475) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000090275
NCBI RefSeq
NM_010290.2
Target Region
Exon 2
Size of Effective Region
~892 bp
Detailed Document
Overview of Gene Research
GJD2, encoding the connexin 36 (Cx36) protein, forms gap junction channels. It is highly expressed in the neural retina and is involved in gap junctional communication and retinal processing of visual signals. The gene is associated with refractive error development, and its study in genetic models can help understand its functions [1].
In zebrafish, depletion of gjd2a (Cx35.5) or gjd2b (Cx35.1) orthologs causes changes in eye biometry and refractive status. Cx35.5 (gjd2a) depletion leads to hyperopia and electrophysiological changes in the retina, while lack of Cx35.1 (gjd2b) causes a nuclear cataract that triggers axial elongation [2].
In conclusion, GJD2 plays a crucial role in refractive error development, as revealed through studies in zebrafish models. Understanding its function can potentially contribute to insights in the field of refractive error-related diseases [2].
References：
1. van der Sande, Emilie, Haarman, Annechien E G, Quint, Wim H, Winkelman, Beerend H J, Iglesias, Adriana I. . The Role of GJD2(Cx36) in Refractive Error Development. In Investigative ophthalmology & visual science, 63, 5. doi:10.1167/iovs.63.3.5. https://pubmed.ncbi.nlm.nih.gov/35262731/
2. Quint, Wim H, Tadema, Kirke C D, de Vrieze, Erik, Klaver, Caroline C W, Iglesias, Adriana I. 2021. Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish. In Communications biology, 4, 676. doi:10.1038/s42003-021-02185-z. https://pubmed.ncbi.nlm.nih.gov/34083742/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen