C57BL/6JCya-F13a1em1/Cya
Common Name
F13a1-KO
Product ID
S-KO-18717
Backgroud
C57BL/6JCya
Strain ID
KOCMP-74145-F13a1-B6J-VA
When using this mouse strain in a publication, please cite “F13a1-KO Mouse (Catalog S-KO-18717) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
F13a1-KO
Strain ID
KOCMP-74145-F13a1-B6J-VA
Gene Name
Product ID
S-KO-18717
Gene Alias
1200014I03Rik, F13a
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000037491
NCBI RefSeq
NM_028784
Target Region
Exon 7
Size of Effective Region
~1.4 kb
Overview of Gene Research
F13a1, encoding coagulation factor XIII A subunit, is crucial in blood coagulation. It cross-links fibrin fibers, supports platelet adhesion, and is involved in angiogenesis and tissue repair pathways [2]. It also plays a role in adipogenesis, with implications for obesity-related adipose tissue expansion and inflammation [1].
In human adipose tissue, F13a1 mRNA expression significantly increases in individuals with acquired excess weight. Its differential expression shows a negative correlation with circulating adiponectin and positive correlations with weight, body fat, and adipocyte size. Transcriptome-wide association studies identify F13a1-associated genes in pathways like cell stress, inflammatory response, and extracellular matrix remodeling [1].
In multiple primary lung cancers, an immunosuppressive F13A1+ macrophage subtype is specifically enriched, which overexpresses M2 macrophage markers and is involved in shaping the immunosuppressive tumor microenvironment [3].
In conclusion, F13a1 is essential for blood coagulation, angiogenesis, and tissue repair. Its role in adipose tissue inflammation and obesity-related processes, as well as in the immunosuppressive tumor microenvironment of multiple primary lung cancers, has been revealed through human-based research. Understanding F13a1's functions provides insights into the mechanisms of these diseases and potential therapeutic targets.
References：
1. Kaartinen, M T, Arora, M, Heinonen, S, Kaprio, J, Pietiläinen, K H. 2020. F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes. In International journal of obesity (2005), 45, 577-587. doi:10.1038/s41366-020-00722-0. https://pubmed.ncbi.nlm.nih.gov/33221826/
2. Gemmati, Donato, Vigliano, Marco, Burini, Francesco, Parmeggiani, Francesco, Serino, Maria L. . Coagulation Factor XIIIA (F13A1): Novel Perspectives in Treatment and Pharmacogenetics. In Current pharmaceutical design, 22, 1449-59. doi:. https://pubmed.ncbi.nlm.nih.gov/26654441/
3. Yang, Chenglin, Qu, Jiahao, Wu, Jingting, Wang, Li, Guo, Xiaotong. . Single-cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers. In Clinical and translational medicine, 14, e70091. doi:10.1002/ctm2.70091. https://pubmed.ncbi.nlm.nih.gov/39601163/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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