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C57BL/6NCya-Selenohem1/Cya
Common Name:
Selenoh-KO
Product ID:
S-KO-18722
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Selenoh-KO
Strain ID
KOCMP-72657-Selenoh-B6N-VA
Gene Name
Selenoh
Product ID
S-KO-18722
Gene Alias
2700094K13Rik; Selh
Background
C57BL/6NCya
NCBI ID
72657
Modification
Conventional knockout
Chromosome
2
Phenotype
MGI:1919907
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Selenohem1/Cya mice (Catalog S-KO-18722) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000117299
NCBI RefSeq
NM_001033166
Target Region
Exon 1~3
Size of Effective Region
~0.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
SELENOH, also known as selenoprotein H and SELH, is a member of the thioredoxin-like family of selenoproteins. Selenoproteins are involved in various functions, with SELENOH potentially playing roles in redox regulation, antioxidant defense, and gene expression regulation in response to redox status [1,5]. It contains a selenocysteine residue in the conserved CXXU motif, which is crucial for its functionally active conformation [5].

In a Selenoh gene knockout (HKO) mouse model, HKO female mice showed a significant decline in cognition, reduced myelin basic protein expression in hippocampal oligodendrocytes, and disrupted hippocampal lipid metabolism, indicating that SELENOH may mediate low selenium-related cognitive decline through these mechanisms [4]. In human colorectal cancer cells, knockdown of SELENOH decreased cellular differentiation, increased proliferation, migration, and the ability to form colonies or tumor xenografts, suggesting SELENOH is a key regulator for cell cycle progression and prevention of uncontrolled proliferation [3]. In the green alga Chlamydomonas reinhardtii, SELENOH-amiRNA knockdown mutants produced more reactive oxygen species (ROS) and grew slower than the wild-type, suggesting it can reduce chromium toxicity by decreasing ROS levels [2].

In conclusion, SELENOH plays essential roles in cognitive function, cell cycle regulation, and redox-related processes. Studies using gene knockout models in mice and knockdown in cell lines have revealed its significance in cognitive decline, tumorigenesis, and response to metal-induced toxicity, providing insights into potential disease mechanisms and the role of selenium-related biology in these conditions.

References:
1. Zhang, Li, Zhu, Jian-Hong, Zhang, Xiong, Cheng, Wen-Hsing. 2018. The Thioredoxin-Like Family of Selenoproteins: Implications in Aging and Age-Related Degeneration. In Biological trace element research, 188, 189-195. doi:10.1007/s12011-018-1521-9. https://pubmed.ncbi.nlm.nih.gov/30229511/
2. Zhang, Baolong, Duan, Guangqian, Fang, Yingying, Yin, Yongguang, Huang, Kaiyao. 2020. Selenium(Ⅳ) alleviates chromium(Ⅵ)-induced toxicity in the green alga Chlamydomonas reinhardtii. In Environmental pollution (Barking, Essex : 1987), 272, 116407. doi:10.1016/j.envpol.2020.116407. https://pubmed.ncbi.nlm.nih.gov/33433342/
3. Bertz, Martin, Kühn, Katrin, Koeberle, Solveigh C, Thierbach, René, Kipp, Anna P. 2018. Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells. In Free radical biology & medicine, 127, 98-107. doi:10.1016/j.freeradbiomed.2018.01.010. https://pubmed.ncbi.nlm.nih.gov/29330096/
4. Lv, Qingqing, Yang, Aolin, Han, Ziyu, Chen, Yuqing, Zhou, Ji-Chang. 2024. Selenoprotein H mediates low selenium-related cognitive decline through impaired oligodendrocyte myelination with disrupted hippocampal lipid metabolism in female mice. In Food & function, 15, 8544-8561. doi:10.1039/d4fo00888j. https://pubmed.ncbi.nlm.nih.gov/39072440/
5. Barage, Sagar H, Deobagkar, Deepti D, Baladhye, Vijay B. 2018. Characterization of structural and functional role of selenocysteine in selenoprotein H and its impact on DNA binding. In Amino acids, 50, 593-607. doi:10.1007/s00726-018-2543-5. https://pubmed.ncbi.nlm.nih.gov/29480333/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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