C57BL/6JCya-Brca1em1/Cya
Common Name
Brca1-KO
Product ID
S-KO-18920
Backgroud
C57BL/6JCya
Strain ID
KOCMP-12189-Brca1-B6J-VA
When using this mouse strain in a publication, please cite “Brca1-KO Mouse (Catalog S-KO-18920) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Brca1-KO
Strain ID
KOCMP-12189-Brca1-B6J-VA
Gene Name
Product ID
S-KO-18920
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000017290
NCBI RefSeq
NM_009764
Target Region
Exon 5~6
Size of Effective Region
~3.5 kb
Overview of Gene Research
BRCA1, short for Breast Cancer 1 protein, is a crucial tumor suppressor gene. It is involved in basic cellular functions like cell replication and DNA synthesis, and is essential for maintaining genome integrity [1,2]. The BRCA1 protein participates in multiple biological pathways, including the DNA damage response, transcriptional control, cell growth, and apoptosis [3].
Mutations in BRCA1 can lead to reduced expression, resulting in impaired mammary gland differentiation and an increased risk of breast and ovarian cancer development [1]. Although it is present in all cells, it remains unclear why its mutations predispose mainly to breast and ovarian cancers [1,2,5]. Intensive research has shown that BRCA1 contributes to DNA repair and transcriptional regulation in response to DNA damage, and is required for the maintenance of chromosomal stability [2].
In conclusion, BRCA1 is vital for normal cellular functions, especially in DNA-related processes. The study of BRCA1, particularly through understanding the effects of its mutations, has significant implications for breast and ovarian cancer research, potentially guiding the development of preventive and therapeutic strategies for these diseases [1,2,4].
References：
1. Romagnolo, Alberto P G, Romagnolo, Donato F, Selmin, Ornella I. . BRCA1 as target for breast cancer prevention and therapy. In Anti-cancer agents in medicinal chemistry, 15, 4-14. doi:. https://pubmed.ncbi.nlm.nih.gov/25329591/
2. Yoshida, Kiyotsugu, Miki, Yoshio. . Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage. In Cancer science, 95, 866-71. doi:. https://pubmed.ncbi.nlm.nih.gov/15546503/
3. Werner, Haim. 2022. BRCA1: An Endocrine and Metabolic Regulator. In Frontiers in endocrinology, 13, 844575. doi:10.3389/fendo.2022.844575. https://pubmed.ncbi.nlm.nih.gov/35432218/
4. Petrova, Dafina, Cruz, Maite, Sánchez, María-José. 2021. BRCA1/2 testing for genetic susceptibility to cancer after 25 years: A scoping review and a primer on ethical implications. In Breast (Edinburgh, Scotland), 61, 66-76. doi:10.1016/j.breast.2021.12.005. https://pubmed.ncbi.nlm.nih.gov/34920368/
5. Sedic, Maja, Kuperwasser, Charlotte. . BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer. In Cell cycle (Georgetown, Tex.), 15, 621-7. doi:10.1080/15384101.2016.1141841. https://pubmed.ncbi.nlm.nih.gov/26822887/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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