Efhc2, the EF-hand domain containing 2 gene, encodes a protein with one predicted calcium-binding EF-hand motif and three DM10 domains. Its function is not fully understood, but it has been implicated in several genetic processes. It may play a role in the regulation of nephron segmentation in zebrafish and is thought to be involved in brain-related genetic diseases [1].

In zebrafish, morpholino antisense oligonucleotide-mediated knock-down of Efhc2 led to defects in pronephros development and function. Specifically, it caused an expansion of the distal early segment of the pronephros, a reduction in the corpuscle of stannius and distal late segments, and a decrease in the number of multi-ciliated cells crucial for fluid flow. These findings suggest Efhc2 is a regulator of distal nephron segmentation and pronephros function during zebrafish development [1].

In conclusion, Efhc2 appears to be important for the distal segmentation of the pronephros in zebrafish, as demonstrated through loss-of-function experiments. While its role in humans is still being explored, it has been associated with brain-related genetic diseases, indicating its potential significance in understanding human genetic disorders [1].