C57BL/6JCya-Igbp1em1/Cya
Common Name
Igbp1-KO
Product ID
S-KO-19438
Backgroud
C57BL/6JCya
Strain ID
KOCMP-18518-Igbp1-B6J-VB
When using this mouse strain in a publication, please cite “Igbp1-KO Mouse (Catalog S-KO-19438) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Igbp1-KO
Strain ID
KOCMP-18518-Igbp1-B6J-VB
Gene Name
Product ID
S-KO-19438
Gene Alias
Pc52, Tap42, p52
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000033570
NCBI RefSeq
NM_008784
Target Region
Exon 3
Size of Effective Region
~1.8 kb
Overview of Gene Research
Immunoglobulin binding protein 1 (IGBP1), an important signal transduction regulator, is associated with multiple biological functions. It is a regulatory subunit of protein phosphatase 2A (Pp2a), sustaining mTOR signaling, and is involved in pathways like the PI3K/AKT pathway [2,4].
IGBP1 has implications in various diseases. In esophageal squamous cell carcinoma (ESCC), its high expression correlates with poor prognosis and is positively associated with T classification and vital status, suggesting it may be a tumor promoter [1]. In lupus nephritis (LN), serum and urine IGBP1 levels are elevated, correlating with proteinuria, renal SLEDAI, and the pathologic activity index, making it a valid biomarker for detecting active nephritis [3,6]. In lung adenocarcinoma, miR-3941 can target IGBP1, suppressing its expression and cell proliferation, indicating miR-3941's role in early-stage lung adenocarcinoma progression [5].
In conclusion, IGBP1 is a crucial molecule involved in multiple biological processes and is significantly associated with diseases like ESCC, LN, and lung adenocarcinoma. Its role as a biomarker and its involvement in disease-related pathways make it an important target for further research, potentially providing new insights for disease diagnosis and treatment.
References：
1. Jiang, Sicong, Li, Daojing, Liang, Zibin, Pei, XiaoFeng, Tang, Jianjun. 2019. High expression of IGBP1 correlates with poor prognosis in esophageal squamous cell carcinoma. In The International journal of biological markers, 35, 33-40. doi:10.1177/1724600819896374. https://pubmed.ncbi.nlm.nih.gov/31875416/
2. Nadel, Guy, Yao, Zhong, Wainstein, Ehud, Horwitz, Benjamin A, Seger, Rony. 2022. GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch. In Cell communication and signaling : CCS, 20, 5. doi:10.1186/s12964-021-00805-z. https://pubmed.ncbi.nlm.nih.gov/34998390/
3. Ebaid, Amany M, Ezzeldin, Nillie, Abdelhady, Enas I, Mohammed, Heba A, Abdallah, Alshimaa L. 2022. Validity of immunoglobulin-binding protein 1 as a biomarker for lupus nephritis. In Lupus, 32, 101-110. doi:10.1177/09612033221141278. https://pubmed.ncbi.nlm.nih.gov/36418233/
4. Grech, Godfrey, Blázquez-Domingo, Montserrat, Kolbus, Andrea, Beug, Hartmut, von Lindern, Marieke. 2008. Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation. In Blood, 112, 2750-60. doi:10.1182/blood-2008-01-133140. https://pubmed.ncbi.nlm.nih.gov/18625885/
5. Sato, Taiki, Shiba-Ishii, Aya, Kim, Yunjung, Iijima, Tatsuo, Noguchi, Masayuki. . miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma. In Cancer science, 108, 536-542. doi:10.1111/cas.13148. https://pubmed.ncbi.nlm.nih.gov/28012229/
6. Lee, Eun-Ju, Kwon, Oh Chan, Ghang, Byeongzu, Yoo, Bin, Kim, Yong-Gil. 2019. Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis. In International journal of molecular sciences, 20, . doi:10.3390/ijms20102606. https://pubmed.ncbi.nlm.nih.gov/31137925/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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