C57BL/6JCya-Glra2em1/Cya
Common Name
Glra2-KO
Product ID
S-KO-19456
Backgroud
C57BL/6JCya
Strain ID
KOCMP-237213-Glra2-B6J-VB
When using this mouse strain in a publication, please cite “Glra2-KO Mouse (Catalog S-KO-19456) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Glra2-KO
Strain ID
KOCMP-237213-Glra2-B6J-VB
Gene Name
Product ID
S-KO-19456
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000058787
NCBI RefSeq
NM_183427
Target Region
Exon 4
Size of Effective Region
~2.1 kb
Overview of Gene Research
Glra2, encoding the glycine receptor α2 subunit, is involved in inhibitory neurotransmission in the adult nervous system and has excitatory action in immature neurons. It plays a role in cortical interneuron migration and generation of excitatory projection neurons in the embryonic brain. Glycine receptors containing this subunit are present in regions like the nucleus accumbens [2,3].
Glra2 knockout mice show myopia-related phenotypes, decreased electroretinogram responses, and impaired retinal rod cell genesis, indicating its role in high myopia. Variants in the gene can cause high myopia by altering visual experience through impairing photoperception and visual transmission [1]. In addition, Glra2 knockout mice exhibit deficits in object recognition memory and impaired long-term potentiation in the prefrontal cortex, suggesting its involvement in non-syndromic autism [2].
In conclusion, Glra2 is crucial for normal neurotransmission, especially in the developing and adult nervous systems. Gene knockout mouse models have revealed its significant roles in high myopia and non-syndromic autism, enhancing our understanding of the underlying mechanisms of these diseases.
References：
1. Tian, Qi, Tong, Ping, Chen, Gong, Xia, Kun, Hu, Zhengmao. 2022. GLRA2 gene mutations cause high myopia in humans and mice. In Journal of medical genetics, 60, 193-203. doi:10.1136/jmedgenet-2022-108425. https://pubmed.ncbi.nlm.nih.gov/35396272/
2. Pilorge, M, Fassier, C, Le Corronc, H, Legendre, P, Betancur, C. 2015. Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. In Molecular psychiatry, 21, 936-45. doi:10.1038/mp.2015.139. https://pubmed.ncbi.nlm.nih.gov/26370147/
3. San Martin, Loreto, Gallegos, Scarlet, Araya, Anibal, Brone, Bert, Aguayo, Luis G. 2020. Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit. In British journal of pharmacology, 177, 3941-3956. doi:10.1111/bph.15136. https://pubmed.ncbi.nlm.nih.gov/32436225/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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