C57BL/6JCya-Desem1/Cya
Common Name:
Des-KO
Product ID:
S-KO-19832
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Des-KO
Strain ID
KOCMP-13346-Des-B6J-VA
Gene Name
Product ID
S-KO-19832
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Desem1/Cya mice (Catalog S-KO-19832) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000027409
NCBI RefSeq
NM_010043
Target Region
Exon 2~5
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
DES, or Diethylstilbestrol, is a transplacental endocrine-disrupting chemical, not a gene. It was a synthetic non-steroidal oestrogen prescribed to pregnant women from the 1940s to prevent miscarriages and other pregnancy disorders, despite lacking proven efficacy [1,2,3,4]. It is classified as carcinogenic to humans and has far-reaching impacts on human health [1].
DES has caused extensive deleterious effects. Pregnant women who took DES, as well as their children and grandchildren, have been affected. It is associated with an increased risk of cancers (such as breast cancer, clear cell adenocarcinoma of the vagina and cervix), abnormalities of the genital tract, neurodevelopmental alterations, problems related to socio-sexual behavior, and immune, pancreatic, and cardiovascular disorders [1]. Epidemiological studies show that in utero exposure to DES can lead to higher risks of preterm delivery, neonatal mortality, stillbirth, malformations, hypospadias in grandsons, and oesophageal atresia or tracheo-oesophageal fistula in grandchildren [2].
In conclusion, DES is a harmful endocrine-disrupting chemical that has had long-lasting and multi-generational effects on human health. The study of its impacts, though not from gene knockout models as it's not a gene, helps us understand the long-term consequences of exposure to such chemicals during pregnancy and the importance of careful drug prescription in the future [1,2,3,4].
References:
1. Zamora-León, Pilar. 2021. Are the Effects of DES Over? A Tragic Lesson from the Past. In International journal of environmental research and public health, 18, . doi:10.3390/ijerph181910309. https://pubmed.ncbi.nlm.nih.gov/34639609/
2. . . Diethylstilbestrol (DES): also harms the third generation. In Prescrire international, 25, 294-298. doi:. https://pubmed.ncbi.nlm.nih.gov/30758926/
3. Al Jishi, Taher, Sergi, Consolato. 2017. Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring. In Reproductive toxicology (Elmsford, N.Y.), 71, 71-77. doi:10.1016/j.reprotox.2017.04.009. https://pubmed.ncbi.nlm.nih.gov/28461243/
4. Veurink, Marieke, Koster, Marlies, Berg, Lolkje T W de Jong-van den. . The history of DES, lessons to be learned. In Pharmacy world & science : PWS, 27, 139-43. doi:. https://pubmed.ncbi.nlm.nih.gov/16096877/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen