C57BL/6JCya-Terf1em1/Cya
Common Name
Terf1-KO
Product ID
S-KO-20415
Backgroud
C57BL/6JCya
Strain ID
KOCMP-21749-Terf1-B6J-VA
When using this mouse strain in a publication, please cite “Terf1-KO Mouse (Catalog S-KO-20415) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Terf1-KO
Strain ID
KOCMP-21749-Terf1-B6J-VA
Gene Name
Product ID
S-KO-20415
Gene Alias
Pin2, Trbf1, Trf1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000188371
NCBI RefSeq
NM_009352
Target Region
Exon 3
Size of Effective Region
~1.1 kb
Overview of Gene Research
TERF1, or Telomeric repeat binding factor 1, is a gene with diverse functions. In plants, as a transcription factor (Tomato Ethylene Responsive Factor 1), it is involved in ethylene-related signaling pathways, playing a crucial role in seed germination [1,3,5]. In animals, it is essential for telomere maintenance and is associated with various cancers [2,4].
In plants, overexpressing TERF1 promotes seed germination. It does so by repressing the ABA signaling pathway through HEXOKINASE 1 (HXK1), activating the plasma membrane (PM) H+-ATPase, and alleviating endoplasmic reticulum (ER) stress to maintain reactive oxygen species (ROS) homeostasis [1]. It also activates the gibberellin acid (GA) signaling pathway independent of GA metabolism under osmotic conditions [3].
In prostate cancer, 6% of localized prostate cancer and 26% of castration-resistant tumors (CRPC) present alterations in TERF1. Amplification/upregulation of TERF1 is associated with the worst prognosis in localized prostate cancer, and miR-155 regulates TERF1 expression in prostate cancer [2]. Also, TERF1 downregulation promotes the migration and invasion of the PC3 prostate cancer cell line via the epithelial-mesenchymal transition (EMT) pathway, as it is a direct target of miR-155 [4].
In conclusion, TERF1 has important functions in both plant seed germination and animal telomere maintenance and cancer-related processes. In plants, it regulates multiple signaling pathways during seed germination. In prostate cancer, its alterations and expression levels are closely related to cancer progression and prognosis, highlighting its potential as a biomarker. Research on TERF1 using various models helps to understand these biological functions and disease mechanisms.
References：
1. Yuan, Long, Liu, Hongzhi, Cao, Yupeng, Wu, Wei. 2023. Transcription factor TERF1 promotes seed germination through HEXOKINASE 1 (HXK1)-mediated signaling pathway. In Journal of plant research, 136, 743-753. doi:10.1007/s10265-023-01471-7. https://pubmed.ncbi.nlm.nih.gov/37233958/
2. Dos Santos, Gabriel Arantes, Viana, Nayara Izabel, Pimenta, Ruan, Leite, Katia Ramos Moreira, Srougi, Miguel. 2021. Prognostic value of TERF1 expression in prostate cancer. In Journal of the Egyptian National Cancer Institute, 33, 24. doi:10.1186/s43046-021-00082-4. https://pubmed.ncbi.nlm.nih.gov/34486082/
3. Liu, Hongzhi, Yuan, Long, Guo, Wei, Wu, Wei. 2022. Transcription factor TERF1 promotes seed germination under osmotic conditions by activating gibberellin acid signaling. In Plant science : an international journal of experimental plant biology, 322, 111350. doi:10.1016/j.plantsci.2022.111350. https://pubmed.ncbi.nlm.nih.gov/35709980/
4. Chen, Wei, He, Li-Na, Liang, Yong, Cheng, Yang, Liu, Jian-Hui. 2020. TERF1 downregulation promotes the migration and invasion of the PC3 prostate cancer cell line as a target of miR‑155. In Molecular medicine reports, 22, 5209-5218. doi:10.3892/mmr.2020.11623. https://pubmed.ncbi.nlm.nih.gov/33174061/
5. Liu, Hongzhi, Wu, Wei. 2021. Comparative transcriptome analysis reveals function of TERF1 in promoting seed germination. In Physiology and molecular biology of plants : an international journal of functional plant biology, 27, 1659-1674. doi:10.1007/s12298-021-01049-4. https://pubmed.ncbi.nlm.nih.gov/34539109/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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