C57BL/6JCya-Dab2em1/Cya
Common Name
Dab2-KO
Product ID
S-KO-20603
Backgroud
C57BL/6JCya
Strain ID
KOCMP-13132-Dab2-B6J-VA
When using this mouse strain in a publication, please cite “Dab2-KO Mouse (Catalog S-KO-20603) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Dab2-KO
Strain ID
KOCMP-13132-Dab2-B6J-VA
Gene Name
Product ID
S-KO-20603
Gene Alias
5730435J12Rik, D15Wsu122e, D630005B22Rik, Doc-2, Doc2, p96
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000080880
NCBI RefSeq
NM_023118
Target Region
Exon 3~4
Size of Effective Region
~2.8 kb
Overview of Gene Research
Dab2, also known as Disabled-2 or DOC-2, is a mitogen-responsive adaptor protein essential for multiple cellular functions. It plays a crucial role in clathrin-mediated endocytosis and is involved in key signalling pathways such as mitogen-activated protein kinase (MAPK), wingless/integrated (Wnt), and transforming growth factor beta (TGFβ) pathways, which are related to homeostasis, cell positioning, and epithelial to mesenchymal transition (EMT) [1,2].
In a Dab2 conditional knockout (Dab2-cKO) mouse model, the hair follicle (HF) cycle was delayed due to perturbed activation of HF stem cells (HFSCs). The number of HFSCs and their colony-forming ability were reduced. The HFSCs in Dab2-cKO mice showed extended quiescence, and the expression of anti-aging genes decreased, suggesting an accelerated aging process. This reveals the role of Dab2 in regulating the activation and self-renewal of HFSCs [3].
In another study, knockdown of DAB2 in human lung fibroblast MRC-5 cells treated with TGF-β1 suppressed cell proliferation and the expression of fibrosis-related proteins. This indicates that DAB2 may play a role in promoting pulmonary fibrosis [4].
In conclusion, Dab2 is a multifunctional protein involved in various cellular functions and signalling pathways. Model-based research, especially the Dab2-cKO mouse model, has revealed its role in processes like HFSC self-renewal and in disease conditions such as pulmonary fibrosis. These findings contribute to understanding the biological functions of Dab2 and its potential implications in disease development.
References：
1. Price, Zoe K, Lokman, Noor A, Yoshihara, Masato, Oehler, Martin K, Ricciardelli, Carmela. 2022. Disabled-2 (DAB2): A Key Regulator of Anti- and Pro-Tumorigenic Pathways. In International journal of molecular sciences, 24, . doi:10.3390/ijms24010696. https://pubmed.ncbi.nlm.nih.gov/36614139/
2. Ogbu, Stella C, Musich, Phillip R, Zhang, Jinyu, Howe, Philip H, Jiang, Yong. 2020. The role of disabled-2 (Dab2) in diseases. In Gene, 769, 145202. doi:10.1016/j.gene.2020.145202. https://pubmed.ncbi.nlm.nih.gov/33059028/
3. Roy, Sayoni, Mehta, Darshan, Paradkar, Akshay, Chovatiya, Gopal, Waghmare, Sanjeev K. 2024. Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells. In Communications biology, 7, 525. doi:10.1038/s42003-024-06047-2. https://pubmed.ncbi.nlm.nih.gov/38702433/
4. Liang, Chun-Lian, Li, Xiu-Li, Quan, Xiao-Juan, Zhang, Lin. 2023. DAB2 promotes pulmonary fibrosis and may act as an intermediate between IGF‑1R and PI3K/AKT signaling pathways. In Experimental and therapeutic medicine, 25, 183. doi:10.3892/etm.2023.11882. https://pubmed.ncbi.nlm.nih.gov/37021069/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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