SD-hGHR
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
SD-hGHR
Product ID
CR008
Gene Name
Background
SD
Gene Alias
GHBP; GHIP
Classification
Other Target Humanized Models,Other Disease Models
NCBI ID
Phenotype
Chromosome
5
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Note: When using this mouse strain in a publication, please cite “SD-hGHR mice (Catalog CR008) were purchased from Cyagen.”
Strain Description
SD-hGHR rats are a humanized model generated using gene editing technology, in which the chimeric human GHR CDS encoding the human-rat chimeric GHR protein and its downstream human 3’UTR sequence were integrated into the rat GHR gene locus. In this model, the chimeric human GHR CDS is composed of the following sequences: the sequence encoding the signal peptide and extracellular domain of the human GHR protein, and the sequence encoding the transmembrane and intracellular domains of the rat GHR protein. Homozygous SD-hGHR rats are viable and fertile, and can be used for studying the pathological mechanisms and therapeutic approaches for endocrine diseases and specific cancers, as well as for the screening, research and development, and preclinical efficacy and safety evaluation of GHR-targeted drugs.
Application Area
GHR-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of endocrine diseases and specific cancers
Validation Data