F9 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
F9 KO
Product ID
C001509
Gene Name
Background
C57BL/6JCya
Gene Alias
FIX; P19; PTC; HEMB; THPH8; F9 p22
Classification
Rare Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “F9 KO mice (Catalog C001509) were purchased from Cyagen.”
Strain Description
F9 KO mice are Hemophilia B disease models constructed by knocking out the mouse F9 gene. F9 KO mice lack F9 mRNA expression and exhibit coagulation dysfunction and other Hemophilia B-related phenotypes. They can be used to study the genetic mechanisms and clinical phenotypes of Hemophilia B in humans and to assist in developing, screening, and evaluating therapeutic drugs. The homozygotes are viable and fertile. Tail docking may lead to significant bleeding. Immediate hemostasis, such as cauterizing the tail incision, is advised to prevent health complications in homozygous mice.
Application Area
Research on Hemophilia B
Validation Data