B6-hITGA4
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hITGA4
Product ID
C001635
Gene Name
Background
C57BL/6NCya
Gene Alias
IA4; CD49D
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hITGA4 mice (Catalog C001635) were purchased from Cyagen.”
Strain Description
The B6-hITGA4 mouse is a humanized model constructed using gene editing technology, where a portion of the mouse Itga4 gene was replaced with "ITGA4 chimera CDS-WPRE-BGH pA" cassette. The murine ITGA4 signal peptide (aa.1~40) was preserved. This model can be used for studying the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases, and for the development of ITGA4-targeted drugs.
Application Area
ITGA4-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases
Validation Data