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B6-hITGA4
Product ID:
C001635
Background:
C57BL/6NCya
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Strain Description
The B6-hITGA4 mouse is a humanized model constructed using gene editing technology, where a portion of the mouse Itga4 gene was replaced with "ITGA4 chimera CDS-WPRE-BGH pA" cassette. The murine ITGA4 signal peptide (aa.1~40) was preserved. This model can be used for studying the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases, and for the development of ITGA4-targeted drugs.
Application Area
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ITGA4-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases
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