B6-hKHK
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hKHK
Product ID
C001642
Gene Name
Background
C57BL/6NCya
Gene Alias
FRUCTU
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hKHK mice (Catalog C001642) were purchased from Cyagen.”
Strain Description
The B6-hKHK mice are a humanized model constructed through gene editing technology, in which the sequence of the mouse Khk gene is replaced in situ with the corresponding sequence of the human KHK gene. Homozygous B6-hKHK mice are viable and fertile. This model can be used for the study of the pathological mechanisms and treatment methods of metabolic diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD), insulin resistance, and obesity, as well as cancer. It can also be applied to the screening, research and development, and safety evaluation of KHK-targeted drugs.
Application Area
Screening, development, and evaluation of KHK-targeted drugs
Research on the pathological mechanisms and treatment methods of metabolic diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD), insulin resistance, obesity, etc., as well as cancer
Validation Data