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B6-h4-1BB/hPDL1
Product ID:
C001686
Background:
C57BL/6N;6JCya
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Strain Description
B6-h4-1BB/hPDL1 mice are TNFRSF9 and CD274 double humanized mouse models obtained by mating TNFRSF9 humanized mouse models (Catalog No. C001604) with CD274 humanized mouse models (Catalog No. C001235). They express human TNFRSF9 and CD274 genomic sequences under the control of mouse promoters. This model is a valuable tool for studying cancer immunotherapy. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting TNFRSF9 and CD274.
Application Area
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4-1BB/PD-L1-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of cancer immunotherapy
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