B6-hα4β7
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hα4β7
Product ID
C001689
Background
C57BL/6NCya
Gene Alias
IA4; CD49D
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hα4β7 mice (Catalog C001689) were purchased from Cyagen.”
Strain Description
B6-hα4β7 mice are ITGA4 and ITGB7 double humanized mouse models obtained by mating ITGA4 humanized mouse models (Catalog No. C001635) with ITGB7 humanized mouse models (Catalog No. C001637). B6-hα4β7 mice express human ITGA4 and ITGB7 genomic sequences under the control of mouse promoters. This model is capable of reproducing human α4β7 and is a valuable tool for studying immune-related diseases. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting α4β7.
Application Area
α4β7-targeted drug screening, development, and evaluation
Research on the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases
Validation Data