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B6-hα4β7
Product ID:
C001689
Background:
C57BL/6NCya
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Strain Description
B6-hα4β7 mice are ITGA4 and ITGB7 double humanized mouse models obtained by mating ITGA4 humanized mouse models (Catalog No. C001635) with ITGB7 humanized mouse models (Catalog No. C001637). B6-hα4β7 mice express human ITGA4 and ITGB7 genomic sequences under the control of mouse promoters. This model is capable of reproducing human α4β7 and is a valuable tool for studying immune-related diseases. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting α4β7.
Application Area
Area
α4β7-targeted drug screening, development, and evaluation
Area
Research on the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases
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