B6-Fgfr3*Y367C
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-Fgfr3*Y367C
Product ID
C001745
Gene Name
Background
C57BL/6NCya
Gene Alias
FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3
Classification
Other Disease Models
NCBI ID
Phenotype
Chromosome
5
Document
Note: When using this mouse strain in a publication, please cite “B6-Fgfr3*Y367C mice (Catalog C001745) were purchased from Cyagen.”
Strain Description
B6-Fgfr3*Y367C mice are obtained by introducing the Y367C mutation into the mouse Fgfr3 gene using gene editing technology. Internal preliminary data show that homozygous B6-Fgfr3*Y367C mice die at 3 weeks. This model can be used to study the mechanisms and therapeutic approaches for diseases such as achondroplasia (ACH) and thanatophoric dysplasia (TD).
Application Area
Research on the disease mechanisms and treatment methods of achondroplasia (ACH) and thanatophoric dysplasia (TD), etc.
Research on Fgfr3 Y367C antagonist
Validation Data