B6-htau*P301S
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-htau*P301S
Product ID
C001836
Gene Name
Background
C57BL/6JCya
Gene Alias
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6
Classification
Full-Gene Humanized Models,Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-htau*P301S mice (Catalog C001836) were purchased from Cyagen.”
Strain Description
This strain is a mouse Mapt gene humanized model carrying P301S mutation and can be used for research on FTD and AD. The homozygous B6-htau*P301S mice are viable and fertile. In addition, based on the independently developed TurboKnockout fusion BAC recombination technology, Cyagen can also generate other hot mutation models (e.g., B6-htau*P301L mice) and provide customized services for specific mutations.
Application Area
Research on Frontotemporal dementia (FTD)
Research on Alzheimer's disease (AD)
Research on other neurodegenerative diseases
Validation Data