NKG-H11-hB2M&HLA-A2.1
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Basic Information
Model Name
NKG-H11-hB2M&HLA-A2.1
Product ID
C001844
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c); HLAA; IMD43
Classification
Immunodeficient Mouse Models
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “NKG-H11-hB2M&HLA-A2.1 mice (Catalog C001844) were purchased from Cyagen.”
Strain Description
NKG-H11-hB2M&HLA-A2.1 mouse is a model constructed via gene editing technology, in which the H2-K1 chimeric HLA-A2.1 gene is knocked into the H11 locus of mice on the NKG strain background. Compared with NKG mice, NKG-H11-hB2M&HLA-A2.1 mice generate functional human T cell subsets with HLA-restricted immune responses after hematopoietic stem cell (HSC) transplantation. Human cytotoxic T lymphocytes (CTLs) developed in immunologically reconstituted mice recognize pathogens in an HLA-restricted manner and exert HLA-restricted cytotoxicity against infected human B cells. This model provides an ideal platform for investigating human immune responses to pathogens, HLA-restricted cytotoxic responses, and related research areas.
Application Area
Construction of immune system humanized mouse models
Research on the human immune system and hematopoietic system
Research on HLA-restricted cytotoxic responses, research on human viral infectious diseases, and development and testing of novel viral vaccines
Research on oncology and autoimmune diseases
Cell line-derived xenograft (CDX) and drug screening and efficacy evaluation
Patient-derived xenograft (PDX) and drug screening and efficacy evaluation
Validation Data