B6-huDNM2
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-huDNM2
Product ID
C001861
Gene Name
Background
C57BL/6NCya
Gene Alias
DYN2; CMT2M; DYNII; LCCS5; CMTDI1; CMTDIB; DI-CMTB
Classification
Full-Gene Humanized Models,Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-huDNM2 mice (Catalog C001861) were purchased from Cyagen.”
Strain Description
B6-huDNM2 mouse is a humanized model constructed via gene editing technology, in which the sequence of the murine Dnm2 gene (from the ATG start codon to the TAG stop codon) is replaced with the sequence of the human DNM2 gene (from the ATG start codon to the 3'UTR). Homozygous males are infertile. B6-huDNM2 mouse can be used for mechanistic research on centronuclear myopathy (CNM) and preclinical studies of DNM2-targeted drugs.
Application Area
Screening, development, and preclinical evaluation of DNM2-targeted drugs
Mechanistic research on centronuclear myopathy (CNM) and evaluation of therapeutic drugs
Validation Data