Acute PKD (inducible)
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Basic Information
Model Name
Acute PKD (inducible)
Product ID
C001889
Gene Name
Background
C57BL/6N;6JCya
Gene Alias
PC1; mFLJ00285
Classification
Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
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Datasheet
Note: When using this mouse strain in a publication, please cite “Acute PKD (inducible) mice (Catalog C001889) were purchased from Cyagen.”
Strain Description
Acute PKD (inducible) mice represent an inducible conditional Pkd1 knockout model generated by crossing Pkd1-floxed mice with kidney-specific, tamoxifen-inducible Cre mice (Cdh16-MerCreMer). Offspring were induced with tamoxifen during lactation to achieve targeted deletion of Pkd1 within renal tubular epithelial cells. Preliminary observations at three weeks post-induction reveal pronounced polycystic kidney disease phenotypes, including the emergence of renal cysts, a marked increase in kidney volume, and elevated serum blood urea nitrogen (BUN) levels. We will continue to monitor this model to assess its late-stage phenotypes and overall disease progression.
Application Area
Research on renal tubular calcium homeostasis and mechanotransduction
Research on renal tubular structure, function, and signal transduction
Research on autosomal dominant polycystic kidney disease (ADPKD)
Research on other renal diseases
Validation Data