B6-hALB/Alpl KO
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Genotype
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Basic Information
Model Name
B6-hALB/Alpl KO
Product ID
C001894
Background
C57BL/6Cya
Gene Alias
HSA; FDAHT; PRO0883; PRO0903; PRO1341; ALP; Akp2; TNAP; Akp-2; APTNAP; TNSALP
Classification
Full-Gene Humanized Models,Metabolic Disease Models,Rare Disease Models
Chromosome
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Datasheet
Note: When using this mouse strain in a publication, please cite “B6-hALB/Alpl KO mice (Catalog C001894) were purchased from Cyagen.”
Strain Description
B6-hALB/Alpl KO mice are generated by crossing B6-hALB (HSA) mice (Catalog No.: C001492) with Alpl KO mice (Catalog No.: C001849). Among them, Alpl KO mice are a gene knockout (KO) model: homozygous Alpl KO mice have a short lifespan, dying within 4 weeks even when fed with special feed; without special feed, no viable homozygous individuals can be obtained. This model can be used for research on the pathogenic mechanisms of diseases such as hypophosphatasia (HPP), osteoporosis, and osteosarcoma (OS), as well as for the development of therapeutic drugs using human serum albumin (HSA) as a carrier, and studies on in vivo efficacy and pharmacokinetics.
Application Area
Research on hypophosphatasia (HPP), osteoporosis, and osteosarcoma (OS)
Design and evaluation of albumin-carrier drugs
Validation Data