B6-hLMNA
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-hLMNA
Product ID
I001124
Gene Name
Background
C57BL/6NCya
Gene Alias
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
Classification
Full-Gene Humanized Models,Other Disease Models
NCBI ID
Phenotype
Chromosome
1
Document
Note: When using this mouse strain in a publication, please cite “B6-hLMNA mice (Catalog I001124) were purchased from Cyagen.”
Strain Description
This strain represents a mouse Lmna gene humanized model, in which the mouse Lmna gene is replaced by the human LMNA gene, including the 3'UTR. It can be employed to investigate the pathogenesis of neuromuscular diseases, heart disease, HGPS, and other disorders, as well as for preclinical evaluation of therapeutic drugs. Homozygous B6-hLMNA mice are viable and fertile.
Application Area
Research on Hutchinson-Gilford Progeria Syndrome (HGPS)
Research on neuromuscular diseases
Research on cardiovascular diseases
Validation Data