H11-Alb-hHSD17B13
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Strain Description
The H11-Alb-hHSD17B13 mouse model is generated by integrating the human HSD17B13 protein coding region (CDS) into the mouse H11 safe harbor locus. The human HSD17B13 gene is specifically expressed in the liver under the regulation of the mouse Alb promoter. This model can be used to study the pathogenic mechanisms of the HSD17B13 gene in metabolic-associated fatty liver disease (MAFLD) and related chronic liver diseases, as well as for evaluating targeted drug development.
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Research on metabolism-associated fatty liver disease (MAFLD), metabolism-associated steatohepatitis (MASH), and other chronic liver diseases
Preclinical evaluation of HSD17B13-targeted drugs
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