B6-hLPA(CKI)/Alb-cre/hPCSK9
Product Type
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Genotype
Sex
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Basic Information
Model Name
B6-hLPA(CKI)/Alb-cre/hPCSK9
Product ID
I002079
Background
C57BL/6NCya
Gene Alias
LP; AK38; APOA; FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3
Classification
Metabolic Target Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
Phenotype
Chromosome
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Note: When using this mouse strain in a publication, please cite “B6-hLPA(CKI)/Alb-cre/hPCSK9 mice (Catalog I002079) were purchased from Cyagen.”
Strain Description
The B6-hLPA (CKI)/Alb-cre/hPCSK9 mouse model is generated by crossing B6-hLPA (CKI) mice (Catalog No.: C001521, a mouse strain with conditional expression of the human LPA gene), Alb-Cre mice (liver-specific Cre-expressing mice), and B6-hPCSK9 mice (Catalog No.: C001617). This model harbors two cardiovascular disease risk factors, namely Lp (a) (lipoprotein (a)) and PCSK9, making it suitable for research on hyperlipidemia, stroke, coronary heart disease, and other atherosclerotic cardiovascular diseases (ASCVD).
Application Area
Hyperlipidemia, stroke, coronary heart disease, familial hypercholesterolemia (FH), and other atherosclerotic cardiovascular diseases (ASCVD)
Development and evaluation of targeted drugs against human Lp (a) and PCSK9
Validation Data