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C57BL/6JCya-Dchs2em1flox/Cya
Common Name:
Dchs2-flox
Product ID:
S-CKO-00158
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Dchs2-flox
Strain ID
CKOCMP-100534287-Dchs2-B6J-VA
Gene Name
Dchs2
Product ID
S-CKO-00158
Gene Alias
EG627094; Gm417; Gm6731
Background
C57BL/6JCya
NCBI ID
100534287
Modification
Conditional knockout
Chromosome
3
Phenotype
MGI:2685263
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dchs2em1flox/Cya mice (Catalog S-CKO-00158) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000191829
NCBI RefSeq
NM_001357165
Target Region
Exon 3
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Dchs2, a dachsous cadherin-related gene, is involved in multiple biological processes. It belongs to the FAT/DCHS family of protocadherins which have high functional redundancy. Dchs2 is important for maintaining cell adhesion and polarity as a cadherin, and is implicated in signaling pathways related to tissue development and growth regulation [2,3].

In the heart, murine DCHS2 deletion induced physiological hypertrophy and promoted cardiomyogenesis, while cardiomyocyte DCHS2 overexpression in zebrafish led to pathological hypertrophy and impaired cardiac regeneration [1]. In hypothalamic-pituitary development, analysis of Dchs2-/-mouse mutants identified anterior pituitary hypoplasia and partially penetrant infundibular defects, implicating Dchs2 in normal hypothalamic-pituitary development [2]. In craniofacial development, zebrafish embryos deficient in Dchs2 showed chondrocytes failing to stack and misregulating sox9a expression, indicating its role in coordinating cartilage differentiation and polarity [4].

In conclusion, Dchs2 plays essential roles in cardiac growth, hypothalamic-pituitary development, and craniofacial development. Gene knockout models, such as the Dchs2-/-mouse mutants, have been crucial in revealing its functions in these specific biological processes, providing insights into related disease mechanisms like heart failure, pituitary gland developmental defects, and skeletal malformations [1,2,4].

References:
1. Li, Haobo, Trager, Lena E, Liu, Xiaojun, González-Rosa, Juan Manuel, Rosenzweig, Anthony. 2022. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. In Circulation, 145, 1218-1233. doi:10.1161/CIRCULATIONAHA.121.056850. https://pubmed.ncbi.nlm.nih.gov/35114812/
2. Lodge, Emily J, Xekouki, Paraskevi, Silva, Tatiane S, Stratakis, Constantine, Andoniadou, Cynthia L. 2020. Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. In JCI insight, 5, . doi:10.1172/jci.insight.134310. https://pubmed.ncbi.nlm.nih.gov/33108146/
3. An, Chang Hyeok, Je, Eun Mi, Yoo, Nam Jin, Lee, Sug Hyung. 2014. Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability. In Pathology oncology research : POR, 21, 181-5. doi:10.1007/s12253-014-9804-8. https://pubmed.ncbi.nlm.nih.gov/24898286/
4. Le Pabic, Pierre, Ng, Carrie, Schilling, Thomas F. 2014. Fat-Dachsous signaling coordinates cartilage differentiation and polarity during craniofacial development. In PLoS genetics, 10, e1004726. doi:10.1371/journal.pgen.1004726. https://pubmed.ncbi.nlm.nih.gov/25340762/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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