C57BL/6JCya-Slc22a7em1flox/Cya
Common Name
Slc22a7-flox
Product ID
S-CKO-00656
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-108114-Slc22a7-B6J-VA
Status
When using this mouse strain in a publication, please cite “Slc22a7-flox Mouse (Catalog S-CKO-00656) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Slc22a7-flox
Strain ID
CKOCMP-108114-Slc22a7-B6J-VA
Gene Name
Product ID
S-CKO-00656
Gene Alias
NLT, OAT2
Background
C57BL/6JCya
Gene Full Name
solute carrier family 22 (organic anion transporter), member 7
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 17 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000087012
NCBI Transcript ID
NM_144856
Target Region
Exon 1~4
Size of Effective Region
~2.5 kb
Overview of Gene Research
Slc22a7, also known as organic anion transporter 2 (OAT2), is a member of the solute carrier superfamily. It plays a crucial role in the transport of various substances, including organic anions, cyclic nucleotides (such as cGMP), nicotinic acid, and creatinine [3,4,5,6]. It is involved in multiple biological processes and pathways, like lipid metabolism, which is associated with its role in diseases such as diabetic kidney disease [1].
In the study of diabetic kidney disease, through transcriptome sequencing in mice, it was found that the mRNA expression level of Slc22a7 declined in the kidney tissues of DKD mice compared with control mice, suggesting its potential role in lipid metabolism and the PPAR signaling pathway in the context of this disease [1]. Also, in Chinese Holstein cows, polymorphisms in Slc22a7 were detected, and they were significantly associated with milk production traits, indicating its possible role in lipid metabolism-related processes in cows [2].
In conclusion, Slc22a7 is an important transporter gene involved in the transport of various substances and plays a role in lipid-related biological processes. Its dysregulation is associated with diseases like diabetic kidney disease, and its genetic variations are related to milk production traits in cows. Research on Slc22a7 using mouse models has provided insights into its function in disease-related biological processes, contributing to a better understanding of disease mechanisms and potentially new treatment strategies for related diseases.
References：
1. Zhao, Jing, He, Kaiying, Du, Hongxuan, Zhou, Xiaochun, Wang, Jianqin. 2022. Bioinformatics prediction and experimental verification of key biomarkers for diabetic kidney disease based on transcriptome sequencing in mice. In PeerJ, 10, e13932. doi:10.7717/peerj.13932. https://pubmed.ncbi.nlm.nih.gov/36157062/
2. Jia, Ruike, Fu, Yihan, Xu, Lingna, Sun, Dongxiao, Han, Bo. 2021. Associations between polymorphisms of SLC22A7, NGFR, ARNTL and PPP2R2B genes and Milk production traits in Chinese Holstein. In BMC genomic data, 22, 47. doi:10.1186/s12863-021-01002-0. https://pubmed.ncbi.nlm.nih.gov/34732138/
3. Sager, Georg, Smaglyukova, Natalia, Fuskevaag, Ole-Martin. 2018. The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes. In Journal of cellular physiology, 233, 5972-5980. doi:10.1002/jcp.26409. https://pubmed.ncbi.nlm.nih.gov/29244191/
4. Mathialagan, Sumathy, Bi, Yi-An, Costales, Chester, Rodrigues, A David, Varma, Manthena V S. 2020. Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7). In Biochemical pharmacology, 174, 113829. doi:10.1016/j.bcp.2020.113829. https://pubmed.ncbi.nlm.nih.gov/32001236/
5. Shen, Hong, Liu, Tongtong, Morse, Bridget L, Marathe, Punit, Lai, Yurong. 2015. Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression. In Drug metabolism and disposition: the biological fate of chemicals, 43, 984-93. doi:10.1124/dmd.114.062364. https://pubmed.ncbi.nlm.nih.gov/25904762/
6. Cropp, Cheryl D, Komori, Takafumi, Shima, James E, More, Swati S, Giacomini, Kathleen M. 2008. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. In Molecular pharmacology, 73, 1151-8. doi:10.1124/mol.107.043117. https://pubmed.ncbi.nlm.nih.gov/18216183/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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