C57BL/6JCya-Crpem1flox/Cya
Common Name:
Crp-flox
Product ID:
S-CKO-01876
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Crp-flox
Strain ID
CKOCMP-12944-Crp-B6J-VA
Gene Name
Product ID
S-CKO-01876
Gene Alias
-
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Crpem1flox/Cya mice (Catalog S-CKO-01876) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000038495
NCBI RefSeq
NM_007768
Target Region
Exon 1~2
Size of Effective Region
~1.9 kb
Detailed Document
Overview of Gene Research
CRP, or C-reactive protein, is a well-known acute-phase protein and a host-defense molecule conserved throughout evolution [1,2,3]. It can mediate phagocytosis initiation by labeling damaged cells, leading to the activation of the classical complement pathway (up to C4) and elimination of pathogens or damaged cells. CRP's binding to ligands like phosphocholine-modified substances and apoptotic cells masks their potentially harmful activities, and it also modulates complement activation, which is beneficial for the body [2]. CRP is a biomarker for inflammation, cardiovascular diseases, and certain cancers [4].
In the context of diseases, elevated CRP levels are associated with myocardial infarction, stroke, COVID-19, hypertension, and atherosclerotic plaque development [1,5]. For example, in "internal wounds" such as myocardial infarction and stroke, CRP can induce tissue damage to potentially regenerable tissue [1]. In COVID-19, CRP labels ischemic but potentially regenerable cells in the lungs [1]. In Nile tilapia, the CRP gene (On-CRP) promotes inflammation, activates the complement pathway, and improves phagocytic and bacterial agglutination activities during bacterial infection [6].
In conclusion, CRP is an evolutionarily conserved protein with important functions in host-defense, inflammation, and disease. Studies across different species and disease models, including those related to COVID-19, myocardial infarction, and hypertension, have revealed its diverse roles. Understanding CRP is crucial for further insights into disease mechanisms and potential therapeutic strategies.
References:
1. Buerke, Michael, Sheriff, Ahmed, Garlichs, Christoph D. 2022. [CRP apheresis in acute myocardial infarction and COVID-19]. In Medizinische Klinik, Intensivmedizin und Notfallmedizin, 117, 191-199. doi:10.1007/s00063-022-00911-x. https://pubmed.ncbi.nlm.nih.gov/35333926/
2. Agrawal, Alok. 2004. CRP after 2004. In Molecular immunology, 42, 927-30. doi:10.1016/j.molimm.2004.09.028. https://pubmed.ncbi.nlm.nih.gov/15829284/
3. Pathak, Asmita, Agrawal, Alok. 2019. Evolution of C-Reactive Protein. In Frontiers in immunology, 10, 943. doi:10.3389/fimmu.2019.00943. https://pubmed.ncbi.nlm.nih.gov/31114584/
4. Rizo-Téllez, Salma A, Sekheri, Meriem, Filep, János G. 2023. C-reactive protein: a target for therapy to reduce inflammation. In Frontiers in immunology, 14, 1237729. doi:10.3389/fimmu.2023.1237729. https://pubmed.ncbi.nlm.nih.gov/37564640/
5. R, Vasanthii, G, Kaarthikeyan, G, Sasirekha, S, Mahalakshmi. 2022. Prevalence of hs-CRP among Indians with hypertension. In Bioinformation, 18, 1041-1043. doi:10.6026/973206300181041. https://pubmed.ncbi.nlm.nih.gov/37654837/
6. Li, Qi, Jiang, Baijian, Zhang, Zhiqiang, Huang, Yu, Jian, Jichang. 2022. CRP Involved in Nile Tilapia (Oreochromis niloticus) against Bacterial Infection. In Biology, 11, . doi:10.3390/biology11081149. https://pubmed.ncbi.nlm.nih.gov/36009776/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen