Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Fabp3em1flox/Cya
Common Name:
Fabp3-flox
Product ID:
S-CKO-02338
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Fabp3-flox
Strain ID
CKOCMP-14077-Fabp3-B6J-VA
Gene Name
Fabp3
Product ID
S-CKO-02338
Gene Alias
Fabph-1; Fabph-4; Fabph1; Fabph4; H-FABP; Mdgi
Background
C57BL/6JCya
NCBI ID
14077
Modification
Conditional knockout
Chromosome
4
Phenotype
MGI:95476
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fabp3em1flox/Cya mice (Catalog S-CKO-02338) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000070532
NCBI RefSeq
NM_010174
Target Region
Exon 2~3
Size of Effective Region
~2.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Fabp3, also known as fatty acid binding protein 3 (muscle and heart), is a cytoplasmic fatty acid binding protein expressed in a tissue-specific manner, predominantly in breast, muscle, and heart. It is involved in various biological processes such as lipid metabolism and transport. By binding fatty acids, it may play a role in intracellular trafficking of lipids, which is crucial for normal cellular function and energy homeostasis [3].

In aged skeletal muscles, FABP3 is upregulated, disrupting homeostasis via lipid remodeling. FABP3 overexpression in young muscles mimics the aged-muscle lipid composition, causing ER stress through the PERK-eIF2α pathway and inhibiting protein synthesis, while FABP3 knockdown in aged muscles reduces ER stress and improves muscle recovery [1].

In mesenchymal stem cells, FABP3 promotes adipogenesis and inhibits osteogenesis. Knockdown of FABP3 alleviates bone loss in aged mice, indicating its role in the bone-fat balance during aging [2].

In the context of cerebral ischemia-reperfusion injury, FABP3 silencing in mice mitigates brain tissue damage, reduces infarct volume ratio, and attenuates neuronal apoptosis, as FABP3 activates mitochondrial autophagy through ROS, leading to mitochondrial dysfunction and neuronal apoptosis [4].

In conclusion, Fabp3 plays essential roles in multiple biological processes, including muscle homeostasis during aging, mesenchymal stem cell fate determination, and the progression of cerebral ischemia-reperfusion injury. The use of gene knockout models in these studies has provided valuable insights into the functions of Fabp3 in these specific disease-related biological processes, highlighting its potential as a therapeutic target for sarcopenia, senile osteoporosis, and stroke-related brain injury.

References:
1. Lee, Seung-Min, Lee, Seol Hee, Jung, Youngae, Lee, Kwang-Pyo, Kwon, Ki-Sun. 2020. FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging. In Nature communications, 11, 5661. doi:10.1038/s41467-020-19501-6. https://pubmed.ncbi.nlm.nih.gov/33168829/
2. Liu, Zheng-Zhao, Hong, Chun-Gu, Hu, Wen-Bao, Hu, Rong-Gui, Xie, Hui. 2020. Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. In Autophagy, 17, 2766-2782. doi:10.1080/15548627.2020.1839286. https://pubmed.ncbi.nlm.nih.gov/33143524/
3. Baru, Ambica, Devi, Chandra, Mukhopadhyay, Tapas, Dogra, Nilambra. 2023. Anti bacterial function of secreted human FABP3. In Biochimica et biophysica acta. General subjects, 1867, 130472. doi:10.1016/j.bbagen.2023.130472. https://pubmed.ncbi.nlm.nih.gov/37788726/
4. Zhong, Fang-Fang, Wei, Bo, Bao, Guo-Xiang, Xiao, Xiao, Tian, Jin-Jin. 2024. FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury. In Neurotoxicity research, 42, 35. doi:10.1007/s12640-024-00712-4. https://pubmed.ncbi.nlm.nih.gov/39008165/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest