C57BL/6JCya-Cxcl5em1flox/Cya
Common Name:
Cxcl5-flox
Product ID:
S-CKO-04966
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Cxcl5-flox
Strain ID
CKOCMP-20311-Cxcl5-B6J-VA
Gene Name
Product ID
S-CKO-04966
Gene Alias
AMCF-II; Cxcl6; ENA-78; GCP-2; LIX; Scyb5; Scyb6
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
5
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cxcl5em1flox/Cya mice (Catalog S-CKO-04966) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000031318
NCBI RefSeq
NM_009141
Target Region
Exon 1~4
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
Cxcl5, also known as C-X-C motif chemokine ligand 5, is a member of the chemokine family. It binds to the G-protein coupled receptor CXCR2. Chemokines are pro-inflammatory cytokines, and Cxcl5 is involved in processes such as immune cell recruitment, angiogenesis, and is of great significance in tumor microenvironment, inflammation-related diseases, and wound healing [1,2].
In the context of gouty arthritis, the CXCL5-neuronal CXCR2-TRPA1 axis contributes to joint pain, neutrophil influx, and inflammation as shown in a mouse model, where CXCL5 expression was increased in ankle joints of gout arthritis model mice [3].
In chronic cerebral ischemia, astrocyte-derived CXCL5 aggravated white matter injury and cognitive decline by inhibiting microglial phagocytosis of myelin debris in conditional knockout (cKO) mice [4].
In diabetes mellitus, CXCL5 suppression promoted neovascularization and wound healing in knockout mice, suggesting its role in diabetic vasculopathy [5].
In conclusion, Cxcl5 plays essential roles in inflammation, angiogenesis, and tissue repair. The study of Cxcl5 knockout or conditional knockout mouse models has significantly contributed to understanding its functions in diseases like gouty arthritis, chronic cerebral ischemia, and diabetes, highlighting its potential as a therapeutic target in these disease areas.
References：
1. Zhang, Wen, Wang, Huishan, Sun, Mingyang, You, Qiang, Miao, Lin. . CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target. In Cancer communications (London, England), 40, 69-80. doi:10.1002/cac2.12010. https://pubmed.ncbi.nlm.nih.gov/32237072/
2. Deng, Jie, Jiang, Rongqi, Meng, Enqing, Wu, Hao. 2022. CXCL5: A coachman to drive cancer progression. In Frontiers in oncology, 12, 944494. doi:10.3389/fonc.2022.944494. https://pubmed.ncbi.nlm.nih.gov/35978824/
3. Yin, Chengyu, Liu, Boyu, Dong, Zishan, Wang, Chuan, Liu, Boyi. 2024. CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis. In Nature communications, 15, 3263. doi:10.1038/s41467-024-47640-7. https://pubmed.ncbi.nlm.nih.gov/38627393/
4. Cao, Qian, Chen, Jian, Zhang, Zhi, Xu, Yun, Qiu, Shuwei. 2023. Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia. In Journal of neuroinflammation, 20, 105. doi:10.1186/s12974-023-02780-3. https://pubmed.ncbi.nlm.nih.gov/37138312/
5. Chen, Ching, Lin, Liang-Yu, Chen, Jaw-Wen, Chang, Ting-Ting. 2023. CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitus. In Cardiovascular diabetology, 22, 172. doi:10.1186/s12933-023-01900-w. https://pubmed.ncbi.nlm.nih.gov/37420254/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen