C57BL/6JCya-Slc39a10em1flox/Cya
Common Name:
Slc39a10-flox
Product ID:
S-CKO-07024
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Slc39a10-flox
Strain ID
CKOCMP-227059-Slc39a10-B6J-VA
Gene Name
Product ID
S-CKO-07024
Gene Alias
2900042E17Rik; 5430433I10; Zip10; mKIAA1265
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc39a10em1flox/Cya mice (Catalog S-CKO-07024) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000027131
NCBI RefSeq
NM_172653
Target Region
Exon 4
Size of Effective Region
~1.1 kb
Detailed Document
Overview of Gene Research
Slc39a10, also known as ZIP10, is a zinc transporter belonging to the SLC39A subfamily. It plays a crucial role in maintaining zinc homeostasis, which is essential for various biological processes. Zinc homeostasis is involved in numerous cellular functions, and Slc39a10 is associated with pathways like MAPK/ERK, PI3K/AKT, and JAK-STAT, influencing processes such as hematopoiesis, immune response, and cell proliferation [1,2,5]. Genetic models, especially knockout (KO) and conditional knockout (CKO) mouse models, have been instrumental in studying its functions.
In zebrafish and mouse models, Slc39a10-deficient animals exhibit more severe impaired hematopoiesis compared to those lacking transferrin receptor 1, highlighting zinc's significant role in hematopoiesis, especially in early hematopoietic stem cells (HSCs). Loss of Slc39a10 in fetal HSCs causes zinc deficiency, leading to DNA damage, apoptosis, and G1 cell cycle arrest, which can be largely restored by zinc supplementation [1]. In macrophage-specific Slc39a10-knockout mice, reduced intracellular zinc concentration leads to p53 stabilization and increased apoptosis upon LPS stimulation, demonstrating its role in macrophage survival during inflammation [3]. T cell-specific deletion of Slc39a10 in transgenic mice protects against disease progression in inflammatory bowel disease (IBD) and experimental autoimmune encephalomyelitis (EAE), and induces massive apoptosis, suggesting its role in T cell-mediated autoimmune diseases [4].
In conclusion, Slc39a10 is essential for processes like hematopoiesis, macrophage and lymphocyte survival, and immune responses. The use of KO and CKO mouse models has provided insights into its role in diseases such as anemia, zinc deficiency-related disorders, autoimmune diseases, and certain cancers. Understanding Slc39a10's functions offers potential therapeutic targets for these disease areas.
References:
1. He, Xuyan, Ge, Chaodong, Xia, Jun, Wang, Fudi, Min, Junxia. 2023. The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10, e2205345. doi:10.1002/advs.202205345. https://pubmed.ncbi.nlm.nih.gov/37068188/
2. Ren, Xiaojuan, Feng, Chao, Wang, Yubo, Ji, Meiju, Hou, Peng. 2023. SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways. In Experimental & molecular medicine, 55, 1757-1769. doi:10.1038/s12276-023-01062-5. https://pubmed.ncbi.nlm.nih.gov/37524874/
3. Gao, Hong, Zhao, Lu, Wang, Hao, Min, Junxia, Wang, Fudi. 2017. Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival. In Proceedings of the National Academy of Sciences of the United States of America, 114, 12940-12945. doi:10.1073/pnas.1708018114. https://pubmed.ncbi.nlm.nih.gov/29180421/
4. Shao, Yichang, Mu, Qingdian, Wang, Rong, Min, Junxia, Wang, Fudi. 2025. SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease. In Science China. Life sciences, , . doi:10.1007/s11427-024-2817-y. https://pubmed.ncbi.nlm.nih.gov/39862347/
5. Miyai, Tomohiro, Hojyo, Shintaro, Ikawa, Tomokatsu, Mishima, Kenji, Fukada, Toshiyuki. 2014. Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. In Proceedings of the National Academy of Sciences of the United States of America, 111, 11780-5. doi:10.1073/pnas.1323549111. https://pubmed.ncbi.nlm.nih.gov/25074913/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen