C57BL/6JCya-Gpr151em1flox/Cya
Common Name
Gpr151-flox
Product ID
S-CKO-08240
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-240239-Gpr151-B6J-VA
Status
When using this mouse strain in a publication, please cite “Gpr151-flox Mouse (Catalog S-CKO-08240) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Gpr151-flox
Strain ID
CKOCMP-240239-Gpr151-B6J-VA
Gene Name
Product ID
S-CKO-08240
Gene Alias
PGR7, GalRL, nGPCR-2037, C130082O03Rik
Background
C57BL/6JCya
Gene Full Name
G protein-coupled receptor 151
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 18 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000054738
NCBI Transcript ID
NM_181543
Target Region
Exon 1
Size of Effective Region
~1.8 kb
Overview of Gene Research
Gpr151, an orphan G protein-coupled receptor, is involved in multiple biological processes. It has been associated with pain modulation, glucose metabolism, and may play a role in social behaviors. It is expressed in various tissues such as the habenula complex, spinal cord neurons, dorsal root ganglia, and the liver [1,2,5,6]. It is also sensitive to acidic conditions [3].
In nociceptive sensory neurons, conditional knockout of Gpr151 in adult mice alleviated chronic constriction injury-induced neuropathic pain-like behavior without affecting basal nociception. Gpr151 was required for chronic constriction injury-induced neuronal hyperexcitability and upregulation of colony-stimulating factor 1 (CSF1), which is necessary for microglial activation in the spinal cord after nerve injury. Mechanistically, it coupled with P2X3 ion channels and promoted their functional activities [1]. In trigeminal neuropathic pain, global mutation or knockdown of Gpr151 in the trigeminal ganglion attenuated partial infraorbital nerve transection-induced mechanical allodynia. Gpr151 bound to Gαi protein and activated the extracellular signal-regulated kinase (ERK) through Gβγ, inducing ERK-dependent neuroinflammation [4].
In the context of glucose metabolism, Gpr151 ablation in mice led to suppression of hepatic gluconeogenesis genes and reduced hepatic glucose production, and restoration of its levels reversed this effect [2]. In social behavior studies, Gpr151 knockout mice showed reduced social preference compared to wild-type mice [6].
In conclusion, Gpr151 plays a key role in pain-related processes, glucose metabolism, and social behaviors. The use of gene knockout (KO) and conditional knockout (CKO) mouse models has been crucial in revealing its functions in neuropathic pain, trigeminal neuropathic pain, glucose metabolism, and social reward. These findings suggest that Gpr151 could be a potential target for treating neuropathic pain and may have implications for understanding glucose metabolism-related disorders and social behavior-related conditions [1,2,4,6].
References：
1. Xia, Li-Ping, Luo, Hao, Ma, Qiang, Hu, Hailan, Xu, Zhen-Zhong. . GPR151 in nociceptors modulates neuropathic pain via regulating P2X3 function and microglial activation. In Brain : a journal of neurology, 144, 3405-3420. doi:10.1093/brain/awab245. https://pubmed.ncbi.nlm.nih.gov/34244727/
2. Bielczyk-Maczynska, Ewa, Zhao, Meng, Zushin, Peter-James H, Svensson, Katrin J, Knowles, Joshua W. 2022. G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis. In Nature communications, 13, 7408. doi:10.1038/s41467-022-35069-9. https://pubmed.ncbi.nlm.nih.gov/36456565/
3. Mashiko, Misaki, Kurosawa, Aya, Tani, Yuki, Tsuji, Takashi, Takeda, Shigeki. . GPR31 and GPR151 are activated under acidic conditions. In Journal of biochemistry, 166, 317-322. doi:10.1093/jb/mvz042. https://pubmed.ncbi.nlm.nih.gov/31119277/
4. Jiang, Bao-Chun, Zhang, Jing, Wu, Bin, Wu, Hao, Gao, Yong-Jing. . G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gβγ/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion. In Pain, 162, 1434-1448. doi:10.1097/j.pain.0000000000002156. https://pubmed.ncbi.nlm.nih.gov/33239523/
5. DePasquale, Olivia, O'Brien, Chris, Gordon, Baila, Barker, David J. 2025. The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological Significance. In ACS chemical neuroscience, 16, 1639-1646. doi:10.1021/acschemneuro.4c00780. https://pubmed.ncbi.nlm.nih.gov/40295925/
6. Allain, Florence, Carter, Michelle, Dumas, Sylvie, Darcq, Emmanuel, Kieffer, Brigitte L. 2022. The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula. In Scientific reports, 12, 20234. doi:10.1038/s41598-022-24395-z. https://pubmed.ncbi.nlm.nih.gov/36424418/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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