C57BL/6JCya-Slc23a4em1flox/Cya
Common Name:
Slc23a4-flox
Product ID:
S-CKO-08537
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc23a4-flox
Strain ID
CKOCMP-243753-Slc23a4-B6J-VA
Gene Name
Product ID
S-CKO-08537
Gene Alias
2010107G12Rik; Gm468
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
6
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc23a4em1flox/Cya mice (Catalog S-CKO-08537) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000044387
NCBI RefSeq
NM_001025573
Target Region
Exon 4
Size of Effective Region
~1.9 kb
Detailed Document
Overview of Gene Research
Slc23a4, also known as sodium-dependent nucleobase transporter 1 (SNBT1), is a gene encoding a sodium-dependent nucleobase transporter. It is involved in the absorption of nucleobases and their analogs in the small intestine, playing a crucial role in the transport and metabolism of nucleobases which are key components of nucleosides and nucleic acids [2,3].
In mice, the targeting of the Slc23a4 gene in Xdh -deficient mice (Xdh(- / -)) was found to be necessary for their survival. Hprt(high)Xdh(- / -)Slc23a4(- / -) mice had a longer lifespan and reached adulthood compared to Xdh(- / -) mice that die of renal failure before 8 weeks of age. These double -knockout mice also had distinct urinary xanthine and hypoxanthine excretion patterns and ratios, along with renal impairment, high plasma creatinine levels, and anemia [1].
In conclusion, Slc23a4 is essential for the intestinal absorption of nucleobases. Gene -knockout mouse models, such as the Hprt(high)Xdh(- / -)Slc23a4(- / -) mice, have revealed its significance in the survival of Xdh -deficient mice and provided insights into the role of Slc23a4 in maintaining normal physiological function related to nucleobase metabolism and preventing renal -related pathologies.
References：
1. Terada, Kazuki, Watanabe, Tamaki, Yasuno, Nobuhiro, Ichida, Kimiyoshi, Hosoyamada, Makoto. 2025. Pseudogenization of the Slc23a4 gene is necessary for the survival of Xdh-deficient mice. In Scientific reports, 15, 3250. doi:10.1038/s41598-025-87751-9. https://pubmed.ncbi.nlm.nih.gov/39863758/
2. Yuasa, Hiroaki, Yasujima, Tomoya, Inoue, Katsuhisa. . Current Understanding of the Intestinal Absorption of Nucleobases and Analogs. In Biological & pharmaceutical bulletin, 43, 1293-1300. doi:10.1248/bpb.b20-00342. https://pubmed.ncbi.nlm.nih.gov/32879202/
3. Yamamoto, Syunsuke, Inoue, Katsuhisa, Murata, Tomoaki, Ohta, Kin-ya, Yuasa, Hiroaki. 2009. Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals. In The Journal of biological chemistry, 285, 6522-31. doi:10.1074/jbc.M109.032961. https://pubmed.ncbi.nlm.nih.gov/20042597/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen