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C57BL/6JCya-Elf4em1flox/Cya
Common Name:
Elf4-flox
Product ID:
S-CKO-12138
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Elf4-flox
Strain ID
CKOCMP-56501-Elf4-B6J-VA
Gene Name
Elf4
Product ID
S-CKO-12138
Gene Alias
Gm9907; Mef
Background
C57BL/6JCya
NCBI ID
56501
Modification
Conditional knockout
Chromosome
X
Phenotype
MGI:1928377
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Elf4em1flox/Cya mice (Catalog S-CKO-12138) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000114958
NCBI RefSeq
NM_001381876
Target Region
Exon 3~4
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Elf4, also known as myeloid elf-1-like factor (MEF), is a member of the ETS transcription factor family. It plays crucial roles in multiple biological processes, including immune response, osteogenesis, adipogenesis, and stem cell quiescence [4]. It is involved in regulating differentiation in osteogenic, adipocyte, and neuronal types, and has a significant impact on the development of the immune system [1].

In the context of diseases, gene knockout (KO) and conditional knockout (CKO) mouse models have provided valuable insights. In Elf4-/-mice, NK cell development, terminal maturation, and function are impaired, establishing ELF4 as necessary for normal NK cell function [2]. Intestinal ELF4 deficiency in mice leads to dysfunction of the intestinal barrier, gut microbiota dysbiosis, and exacerbation of alcoholic liver disease, indicating its role in maintaining gut homeostasis [3]. In IBD-related studies, bioinformatics and in-vivo tests showed that ELF4 overexpression reduced mouse intestinal inflammation by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization [5].

In conclusion, Elf4 is essential for normal immune cell development, gut homeostasis, and regulation of inflammation. KO and CKO mouse models have been instrumental in revealing its role in diseases such as NK cell deficiency, alcoholic liver disease, and inflammatory bowel disease, providing a basis for understanding disease mechanisms and potential therapeutic targets.

References:
1. Hu, Dian, Zhang, Zerui, Wang, Yijun, Huang, Wenjie, Xia, Limin. 2024. Transcription factor ELF4 in physiology and diseases: Molecular roles and clinical implications. In Genes & diseases, 12, 101394. doi:10.1016/j.gendis.2024.101394. https://pubmed.ncbi.nlm.nih.gov/40083328/
2. Salinas, Sandra Andrea, Mace, Emily M, Conte, Matilde I, Lacorazza, H Daniel, Orange, Jordan S. 2022. An ELF4 hypomorphic variant results in NK cell deficiency. In JCI insight, 7, . doi:10.1172/jci.insight.155481. https://pubmed.ncbi.nlm.nih.gov/36477361/
3. Liu, Tongtong, Yu, Haitao, Zhang, Zeming, Yang, Long, You, Fuping. 2022. Intestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis. In International journal of molecular sciences, 23, . doi:10.3390/ijms23094825. https://pubmed.ncbi.nlm.nih.gov/35563234/
4. Suico, Mary Ann, Shuto, Tsuyoshi, Kai, Hirofumi. . Roles and regulations of the ETS transcription factor ELF4/MEF. In Journal of molecular cell biology, 9, 168-177. doi:10.1093/jmcb/mjw051. https://pubmed.ncbi.nlm.nih.gov/27932483/
5. Cao, Meiwan, Chen, Peiyu, Peng, Baoling, Geng, Lanlan, Gong, Sitang. 2023. The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization. In Frontiers in immunology, 14, 1270411. doi:10.3389/fimmu.2023.1270411. https://pubmed.ncbi.nlm.nih.gov/38022496/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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