Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Fam162aem1flox/Cya
Common Name:
Fam162a-flox
Product ID:
S-CKO-14749
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Fam162a-flox
Strain ID
CKOCMP-70186-Fam162a-B6J-VA
Gene Name
Fam162a
Product ID
S-CKO-14749
Gene Alias
2310056P07Rik; HGTD-P
Background
C57BL/6JCya
NCBI ID
70186
Modification
Conditional knockout
Chromosome
16
Phenotype
MGI:1917436
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fam162aem1flox/Cya mice (Catalog S-CKO-14749) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000004057
NCBI RefSeq
NM_027342
Target Region
Exon 4
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Fam162a, with its specific function yet to be fully elucidated, has been associated with several biological processes. It has been linked to hypoxia-related pathways, glycolysis-related processes, and may play a role in apoptosis regulation. Its involvement in these pathways indicates its importance in maintaining cellular homeostasis and response to various stressors [2,3,4,5,6,7,8,9].

In the context of disease, in patients with inflammatory bowel disease (IBD), Fam162a was identified as one of the 10 marker genes potentially contributing to intestinal barrier repairing, with its expression specific to absorptive cell types in intestinal epithelium [1]. In coronary artery disease (CAD), it was among 4 hub signature genes identified as hypoxia-related genes, and was found to be highly expressed in endothelial cells [2]. In osteosarcoma, a gene signature including Fam162a was constructed related to hypoxia and lactate metabolism, with high-risk scores (where Fam162a was part of the signature) associated with poor prognosis and "cold" tumor characteristics [3]. In IDH-mutant glioma, a hypoxia-related survival score containing Fam162a was identified, which could predict survival independent of other prognostic factors [4]. In colon cancer, Fam162a was part of a 13-gene glycolysis-related prognostic prediction model [5]. In a study on the mechanism of neuronal apoptosis in chronic cerebral ischemia, Foxh1 was shown to transcriptionally promote the expression of Fam162a [6]. In tilapia, differential exon usages of fam162a were detected in response to acute hypoxia treatment in the heart [7]. In mouse neuroblastoma Neuro-2a cells exposed to a mitochondrial toxin, there was a loss of FAM162a mRNA along with changes in mitochondrial-related genes [8]. In osteosarcoma, a risk model based on seven glycolytic genes including Fam162a could effectively evaluate prognosis [9].

In conclusion, Fam162a is implicated in multiple biological processes and disease conditions, especially those related to hypoxia, glycolysis, and tissue repair or tumor prognosis. Studies across different disease models have revealed its potential as a biomarker or therapeutic target in diseases such as IBD, CAD, osteosarcoma, IDH-mutant glioma, and colon cancer. Understanding the function of Fam162a through these disease-based research models provides insights into the underlying molecular mechanisms of these diseases.

References:
1. Zhao, Xiao-Hu, Zhao, Peinan, Deng, Zihao, Sun, Da-Li, He, Hai-Yu. 2023. Integrative analysis reveals marker genes for intestinal mucosa barrier repairing in clinical patients. In iScience, 26, 106831. doi:10.1016/j.isci.2023.106831. https://pubmed.ncbi.nlm.nih.gov/37250791/
2. Jin, Yuqing, Ren, Weiyan, Liu, Jiayi, Hou, Lianguo, Yang, Lei. 2023. Identification and validation of potential hypoxia-related genes associated with coronary artery disease. In Frontiers in physiology, 14, 1181510. doi:10.3389/fphys.2023.1181510. https://pubmed.ncbi.nlm.nih.gov/37637145/
3. Wang, Yizhuo, Wang, Xin, Liu, Yang, Zheng, Yufu, Qi, Quan. 2024. A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma. In Frontiers in immunology, 15, 1467052. doi:10.3389/fimmu.2024.1467052. https://pubmed.ncbi.nlm.nih.gov/39569192/
4. Dao Trong, Philip, Rösch, Saskia, Mairbäurl, Heimo, Herold-Mende, Christel, Warta, Rolf. 2018. Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma. In International journal of molecular sciences, 19, . doi:10.3390/ijms19102903. https://pubmed.ncbi.nlm.nih.gov/30257451/
5. Liu, Gang, Wu, Xiaoyang, Chen, Jian. 2022. Identification and validation of a glycolysis-related gene signature for depicting clinical characteristics and its relationship with tumor immunity in patients with colon cancer. In Aging, 14, 8700-8718. doi:10.18632/aging.204226. https://pubmed.ncbi.nlm.nih.gov/35963622/
6. Yang, Jin, Liu, Xiaobai, Zhao, Yubo, Cui, Zheng, Liu, Yunhui. 2023. Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia. In Cell biology and toxicology, 39, 2881-2898. doi:10.1007/s10565-023-09807-8. https://pubmed.ncbi.nlm.nih.gov/37097350/
7. Xia, Jun Hong, Li, Hong Lian, Li, Bi Jun, Gu, Xiao Hui, Lin, Hao Ran. 2017. Acute hypoxia stress induced abundant differential expression genes and alternative splicing events in heart of tilapia. In Gene, 639, 52-61. doi:10.1016/j.gene.2017.10.002. https://pubmed.ncbi.nlm.nih.gov/28986317/
8. Mazzio, E, Soliman, K F A. 2012. Whole genome expression profile in neuroblastoma cells exposed to 1-methyl-4-phenylpyridine. In Neurotoxicology, 33, 1156-69. doi:10.1016/j.neuro.2012.06.009. https://pubmed.ncbi.nlm.nih.gov/22776087/
9. Huang, Wei, Xiao, Yingqi, Wang, Hongwei, Chen, Guanghui, Li, Kaixiang. 2022. Identification of risk model based on glycolysis-related genes in the metastasis of osteosarcoma. In Frontiers in endocrinology, 13, 1047433. doi:10.3389/fendo.2022.1047433. https://pubmed.ncbi.nlm.nih.gov/36387908/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest