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C57BL/6JCya-Dcp2em1flox/Cya
Common Name:
Dcp2-flox
Product ID:
S-CKO-14885
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Dcp2-flox
Strain ID
CKOCMP-70640-Dcp2-B6J-VA
Gene Name
Dcp2
Product ID
S-CKO-14885
Gene Alias
2410015D23Rik; 5730537H01Rik
Background
C57BL/6JCya
NCBI ID
70640
Modification
Conditional knockout
Chromosome
18
Phenotype
MGI:1917890
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dcp2em1flox/Cya mice (Catalog S-CKO-14885) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025350
NCBI RefSeq
NM_027490
Target Region
Exon 2
Size of Effective Region
~1.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Dcp2, the major mRNA decapping enzyme in eukaryotic cells, plays a crucial role in regulating cellular mRNA levels. Eukaryotic mRNAs have a 5' cap structure that protects against exonucleolytic degradation, and Dcp2-through interactions with activators like Dcp1, Edc1, and Edc3, as well as an autoinhibition mechanism-controls the mRNA decapping pathways [1]. This process is vital for numerous biological functions such as the tight control of LINE-1 mobilization in maintaining genetic stability [2], and the regulation of chemoresistance in small cell lung cancer [3], and neuronal apoptosis in chronic cerebral ischemia [4].

In yeast, genetic analyses have shown that Dcp2 C-terminal domain cis-regulatory elements control decapping enzyme target specificity by forming distinct decapping complexes, with Upf1, Edc3, Scd6, and Pat1 acting as regulatory subunits controlling substrate specificity and enzymatic activation [5]. RNA-Seq and ribosome profiling in dcp2Δ yeast cells revealed that Dcp2 affects mRNA abundance and translation, adjusting metabolism and filamentation according to nutrient availability [6]. In mammalian cells, reduced Dcp2 levels led to increased mRNA and protein levels of key type I IFN transcription factor IRF-7, suggesting Dcp2 modulates IRF-7 mRNA stability and may negatively contribute to the innate immune response in a negative feedback mechanism [7].

In conclusion, Dcp2 is essential for regulating mRNA stability and translation, influencing various biological processes and disease-related pathways. Studies using gene-knockout models in yeast and reduced-expression models in mammalian cells have provided insights into its role in processes like genetic stability maintenance, chemoresistance, neuronal apoptosis, and the innate immune response.

References:
1. Wurm, Jan Philip, Sprangers, Remco. 2019. Dcp2: an mRNA decapping enzyme that adopts many different shapes and forms. In Current opinion in structural biology, 59, 115-123. doi:10.1016/j.sbi.2019.07.009. https://pubmed.ncbi.nlm.nih.gov/31473440/
2. Liu, Qian, Yi, Dongrong, Ding, Jiwei, Peng, Xiaozhong, Cen, Shan. 2023. MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large cytoplasmic granules with phase separation properties. In EMBO reports, 24, e56512. doi:10.15252/embr.202256512. https://pubmed.ncbi.nlm.nih.gov/37437058/
3. Sun, Yueqin, Shen, Weitao, Hu, Shulu, Zhu, Weiliang, Zhang, Jian. 2023. METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy. In Journal of experimental & clinical cancer research : CR, 42, 65. doi:10.1186/s13046-023-02638-9. https://pubmed.ncbi.nlm.nih.gov/36932427/
4. Yang, Jin, Liu, Xiaobai, Zhao, Yubo, Cui, Zheng, Liu, Yunhui. 2023. Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia. In Cell biology and toxicology, 39, 2881-2898. doi:10.1007/s10565-023-09807-8. https://pubmed.ncbi.nlm.nih.gov/37097350/
5. He, Feng, Wu, Chan, Jacobson, Allan. 2022. Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes. In eLife, 11, . doi:10.7554/eLife.74410. https://pubmed.ncbi.nlm.nih.gov/35604319/
6. Vijjamarri, Anil Kumar, Niu, Xiao, Vandermeulen, Matthew D, Lin, Zhenguo, Hinnebusch, Alan G. 2023. Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.01.05.522830. https://pubmed.ncbi.nlm.nih.gov/36711592/
7. Li, You, Dai, Jihong, Song, Mangen, Fitzgerald-Bocarsly, Patricia, Kiledjian, Megerditch. 2012. Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7. In Molecular and cellular biology, 32, 1164-72. doi:10.1128/MCB.06328-11. https://pubmed.ncbi.nlm.nih.gov/22252322/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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