Dnajc18 is a member of the type III DnaJ family protein. It is involved in various biological functions, and its study using genetic models like KO or CKO mouse models can help understand its role in different processes. In rats, it is specifically expressed in male germ cells, potentially playing a role during germ cell maturation in adult rat testis [1].

Mutations in Dnajc18 in mice show developmental cardiac structural abnormalities, validating the importance of the DNAJC18 gene for cardiac homeostasis as its loss of function is associated with altered left ventricular systolic function [2]. Additionally, in studies related to various cattle breeds, DnaJC18 is associated with heat tolerance, immune response, and adaptation to different environments [3,4,5,6,7,9]. In Ethiopian indigenous sheep, it is related to response to heat stress [8].

In conclusion, Dnajc18 is significant in germ cell maturation in rats and cardiac homeostasis in mice. Its association with heat tolerance, immune response, and adaptation in livestock indicates its importance in different species' environmental adaptation and physiological processes. Studies on Dnajc18 using genetic models contribute to understanding these biological functions and disease-related conditions.