C57BL/6JCya-Myhasem1flox/Cya
Common Name:
Myhas-flox
Product ID:
S-CKO-18093
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Myhas-flox
Strain ID
CKOCMP-102633540-Myhas-B6J-VA
Gene Name
Product ID
S-CKO-18093
Gene Alias
Gm12300; lnc-mg
Background
C57BL/6JCya
NCBI ID
Modification
Conditional knockout
Chromosome
11
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Myhasem1flox/Cya mice (Catalog S-CKO-18093) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000149070
NCBI RefSeq
NR_146138
Target Region
Exon 1
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Myhas, likely a long non-coding RNA (lncRNA), may play a regulatory role in myosin heavy chain (MHC) gene expression. MHC is crucial for muscle function, and Myhas, as an antisense transcript, could potentially be involved in mechanisms that regulate shifts in MHC gene expression in response to exercise training [3].
In the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS), the progression of Myhas RNA levels across disease stages correlated with longevity. It effectively discriminated between long-and short-term survival individuals, suggesting its potential as a prognostic indicator for ALS [1].
In laryngeal cancer, Myhas appears to be a protective factor. A 4-lncRNA signature including Myhas was developed to predict the prognosis of patients, and functional annotation analysis suggested that the mechanisms may involve extracellular exosome, Notch, voltage-gated calcium channels, and Wnt signaling pathways [2].
In conclusion, Myhas seems to have important functions in both normal muscle-related regulation and disease contexts. In ALS, it shows promise as a prognostic biomarker, and in laryngeal cancer, it may protect against the disease through various signaling pathways. Research on Myhas using animal models like the SOD1G93A mouse model has provided valuable insights into its role in disease processes.
References:
1. López-Royo, Tresa, Moreno-Martínez, Laura, Zaragoza, Pilar, Manzano, Raquel, Osta, Rosario. 2024. Differentially expressed lncRNAs in SOD1G93A mice skeletal muscle: H19, Myhas and Neat1 as potential biomarkers in amyotrophic lateral sclerosis. In Open biology, 14, 240015. doi:10.1098/rsob.240015. https://pubmed.ncbi.nlm.nih.gov/39406341/
2. Zhang, Guihai, Fan, Erxi, Zhong, Qiuyue, Chen, Qiying, Gou, Xiaoxia. 2019. Identification and potential mechanisms of a 4-lncRNA signature that predicts prognosis in patients with laryngeal cancer. In Human genomics, 13, 36. doi:10.1186/s40246-019-0230-6. https://pubmed.ncbi.nlm.nih.gov/31416476/
3. Pandorf, Clay E, Haddad, Fadia, Owerkowicz, Tomasz, Baldwin, Kenneth M, Adams, Gregory R. 2020. Regulation of myosin heavy chain antisense long noncoding RNA in human vastus lateralis in response to exercise training. In American journal of physiology. Cell physiology, 318, C931-C942. doi:10.1152/ajpcell.00166.2018. https://pubmed.ncbi.nlm.nih.gov/32130073/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen