C57BL/6JCya-Tacr3em1flox/Cya
Common Name
Tacr3-flox
Product ID
S-CKO-18399
Backgroud
C57BL/6JCya
Strain ID
CKOCMP-21338-Tacr3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Tacr3-flox Mouse (Catalog S-CKO-18399) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Tacr3-flox
Strain ID
CKOCMP-21338-Tacr3-B6J-VA
Gene Name
Product ID
S-CKO-18399
Gene Alias
Nkr, Nk3r, Tac3r
Background
C57BL/6JCya
Gene Full Name
tachykinin receptor 3
Modification
Conditional knockout
NCBI ID
Phenotype
Chromosome
Chr 3 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000029822
NCBI Transcript ID
NM_021382
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Overview of Gene Research
Tacr3 encodes tachykinin receptor 3 (NK3R), belonging to the tachykinin receptor family within the rhodopsin subfamily of G protein-coupled receptors. It functions by binding to its high-affinity ligand, neurokinin B (NKB), and is involved in various biological processes. In growth and reproduction, it has been well-studied, and also plays roles in the nervous system, participating in physiological and pathological processes like mood disorders, chronic pain, and neurodegenerative diseases [1].
In a mouse model of trigeminal neuralgia, downregulation of Tacr3 in the lateral habenula (LHb) was observed, and rescuing this downregulation by overexpressing Tacr3 in the unilateral LHb reversed anxiety-like behaviors but not allodynia. Bilateral Tacr3 overexpression in the LHb alleviated both allodynia and anxiety-like behaviors, suggesting Tacr3 in the LHb suppresses the hyperexcitability of LHb neurons and plays a protective role [3]. In rats, severe anxiety is linked to dampened TACR3 expression in the ventral hippocampus, and TACR3 expression is sensitive to sex hormones. Inhibition of TACR3 activity affects synaptic activity, spine density, and long-term potentiation (LTP), indicating its role in regulating anxiety-associated synaptic plasticity [2].
In conclusion, Tacr3 is essential in regulating reproduction-related functions and has a significant impact on the nervous system, especially in relation to mood-related behaviors and synaptic plasticity. The study of Tacr3 in mouse models has provided valuable insights into its role in conditions such as trigeminal neuralgia-related mood disorders and anxiety-associated neural changes, which may offer potential therapeutic targets for these diseases.
References：
1. Zhang, Wen-Wen, Wang, Yanqing, Chu, Yu-Xia. 2020. Tacr3/NK3R: Beyond Their Roles in Reproduction. In ACS chemical neuroscience, 11, 2935-2943. doi:10.1021/acschemneuro.0c00421. https://pubmed.ncbi.nlm.nih.gov/32926772/
2. Wojtas, Magdalena Natalia, Diaz-González, Marta, Stavtseva, Nadezhda, Veksler-Lublinsky, Isana, Knafo, Shira. 2023. Interplay between hippocampal TACR3 and systemic testosterone in regulating anxiety-associated synaptic plasticity. In Molecular psychiatry, 29, 686-703. doi:10.1038/s41380-023-02361-z. https://pubmed.ncbi.nlm.nih.gov/38135756/
3. Cui, Wen-Qiang, Zhang, Wen-Wen, Chen, Teng, Wang, Yan-Qing, Chu, Yu-Xia. 2020. Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. In Acta neuropathologica communications, 8, 44. doi:10.1186/s40478-020-00922-9. https://pubmed.ncbi.nlm.nih.gov/32264959/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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