Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Hes7em1flox/Cya
Common Name:
Hes7-flox
Product ID:
S-CKO-19254
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Hes7-flox
Strain ID
CKOCMP-84653-Hes7-B6J-VB
Gene Name
Hes7
Product ID
S-CKO-19254
Gene Alias
bHLHb37
Background
C57BL/6JCya
NCBI ID
84653
Modification
Conditional knockout
Chromosome
11
Phenotype
MGI:2135679
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Hes7em1flox/Cya mice (Catalog S-CKO-19254) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000024543
NCBI RefSeq
NM_033041
Target Region
Exon 2~4
Size of Effective Region
~1.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Hes7, a basic helix-loop-helix (bHLH)-type repressor gene, is regulated by Notch and expressed in the presomitic mesoderm [6]. It is a key segmentation clock gene that controls the periodic formation of somites, which are crucial for the proper development of the vertebrae [1]. Somitogenesis, regulated by the oscillatory expression of Hes7, is associated with the Fgf and Notch signaling pathways [2].

Mouse models have provided significant insights into Hes7 function. In knock-in mice where Hes7 3'UTR was disrupted, proper splicing was affected, leading to reduced Hes7 protein levels, damped oscillation, and improper periodic somite segmentation, demonstrating the importance of 3'UTR for normal Hes7 function [5]. Mice expressing mutant Hes7 with a longer half-life showed severely disorganized somite segmentation and oscillatory expression after a few normal cycles, highlighting the essential role of Hes7 protein instability for sustained oscillation and its function as a segmentation clock [7]. Additionally, Fgf4 mutants, which display vertebral defects, show that Fgf4 maintains Hes7 levels and normal oscillatory patterns, indicating a genetic synergy between Hes7 and Fgf4 [4].

In conclusion, Hes7 is essential for the somite segmentation clock during vertebrate development. Mouse models, including those with disrupted 3'UTR or altered protein stability, have revealed its role in normal somitogenesis. Understanding Hes7 function is relevant to human congenital spine diseases, such as spondylocostal dysostosis 4, caused by HES7 variants, emphasizing the importance of Hes7-related research for disease understanding [3].

References:
1. Sanaki-Matsumiya, Marina, Kageyama, Ryoichiro. . Time-Lapse Bioluminescence Imaging of Hes7 Expression In Vitro and Ex Vivo. In Methods in molecular biology (Clifton, N.J.), 2525, 321-332. doi:10.1007/978-1-0716-2473-9_25. https://pubmed.ncbi.nlm.nih.gov/35836080/
2. Harima, Yukiko, Kageyama, Ryoichiro. 2013. Oscillatory links of Fgf signaling and Hes7 in the segmentation clock. In Current opinion in genetics & development, 23, 484-90. doi:10.1016/j.gde.2013.02.005. https://pubmed.ncbi.nlm.nih.gov/23465881/
3. Lv, Shaoguang, Wu, Yuanyuan, Liu, Fang, Jiao, Baoquan. 2023. A novel homozygous HES7 splicing variant causing spondylocostal dysostosis 4: a case report. In Frontiers in pediatrics, 11, 1201999. doi:10.3389/fped.2023.1201999. https://pubmed.ncbi.nlm.nih.gov/37691774/
4. Anderson, Matthew J, Magidson, Valentin, Kageyama, Ryoichiro, Lewandoski, Mark. 2020. Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function. In eLife, 9, . doi:10.7554/eLife.55608. https://pubmed.ncbi.nlm.nih.gov/33210601/
5. Fujimuro, Takeshi, Matsui, Takaaki, Nitanda, Yasuhide, Nakahata, Yasukazu, Bessho, Yasumasa. 2014. Hes7 3'UTR is required for somite segmentation function. In Scientific reports, 4, 6462. doi:10.1038/srep06462. https://pubmed.ncbi.nlm.nih.gov/25248974/
6. Bessho, Y, Miyoshi, G, Sakata, R, Kageyama, R. . Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. In Genes to cells : devoted to molecular & cellular mechanisms, 6, 175-85. doi:. https://pubmed.ncbi.nlm.nih.gov/11260262/
7. Hirata, Hiromi, Bessho, Yasumasa, Kokubu, Hiroshi, Lewis, Julian, Kageyama, Ryoichiro. 2004. Instability of Hes7 protein is crucial for the somite segmentation clock. In Nature genetics, 36, 750-4. doi:. https://pubmed.ncbi.nlm.nih.gov/15170214/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest